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SB-209670

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Catalog No. T34541Cas No. 157659-79-5
Alias SB 209670

SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.

SB-209670

SB-209670

🥰Excellent
Purity: 99.24%
Catalog No. T34541Alias SB 209670Cas No. 157659-79-5
SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.
Pack SizePriceAvailabilityQuantity
1 mg$350In Stock
5 mg$828In Stock
10 mg$1,130In Stock
25 mg$1,590In Stock
50 mg$1,980In Stock
100 mg$2,500In Stock
500 mg$4,900In Stock
1 mL x 10 mM (in DMSO)$838In Stock
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Purity:99.24%
ee:100%
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Product Introduction

Bioactivity
Description
SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.
In vivo
SB 209670 (3 mg kg-1, i.v. bolus + 100 micrograms kg-1, i.v. infusion commencing 15 min prior to LPS ; rats) significantly augmented the hypotension as well as the vascular hyporeactivity to NA caused by endotoxaemia.[5]
SB 209670 (3 mg kg-1, i.v. bolus given 15 min prior to LPS ; LPS-rats) resulted in a reduction in 6 h-survival from 71% (control) to 30% and 13%, respectively.[5]
SB 209670 (3 mg kg-1, i.v. bolus 15 min prior to LPS ; rats) significantly augmented the serum levels of creatinine, bilirubin, GPT and GOT caused by endotoxin.[5]
SB 209670 (3 mg kg-1, i.v. bolus ; rats) significantly augmented the metabolic acidosis caused by LPS.[5]
AliasSB 209670
Chemical Properties
Molecular Weight520.53
FormulaC29H28O9
Cas No.157659-79-5
SmilesC(O)(=O)[C@H]1[C@@H](C=2C([C@@H]1C=3C=C4C(=CC3)OCO4)=CC=C(OCCC)C2)C5=C(OCC(O)=O)C=C(OC)C=C5
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 27.5 mg/mL (52.83 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9211 mL9.6056 mL19.2112 mL96.0559 mL
5 mM0.3842 mL1.9211 mL3.8422 mL19.2112 mL
10 mM0.1921 mL0.9606 mL1.9211 mL9.6056 mL
20 mM0.0961 mL0.4803 mL0.9606 mL4.8028 mL
50 mM0.0384 mL0.1921 mL0.3842 mL1.9211 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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