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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $133 | In Stock | |
5 mg | $296 | In Stock | |
10 mg | $498 | In Stock | |
25 mg | $953 | In Stock | |
50 mg | $1,230 | In Stock | |
100 mg | $1,610 | In Stock |
Description | Clazosentan (Ro 61-1790) is a specific endothelin A (ETA) receptor antagonist that inhibits ET-1-mediated vasospasm.Clazosentan is used in the study of neurological and cardiovascular diseases. |
In vitro | Clazosentan is an effective competitive antagonist of ET ( A ) receptor-mediated ET-1 and its precursor large ET-1 on cerebral vasoconstriction[2]. |
In vivo | In Rats, Clazosentan ( 10 μM, 0.05 mL / kg ; intracisternal injection ) Inhibited the contractile responses to ET-1, without preventing SAH-induced upregulation of ET receptors in cerebral arteries[2]. |
Alias | VML 588, AXV-034343, Ro 61-1790 |
Molecular Weight | 577.57 |
Formula | C25H23N9O6S |
Cas No. | 180384-56-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (103.88 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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