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Clazosentan
Catalog No. T64084Cas No. 180384-56-9
Alias VML 588, Ro 61-1790, AXV-034343
Clazosentan (Ro 61-1790) is a selective antagonist of the endothelin A receptor (ETAreceptor) that inhibits ET-1-mediated vasoconstriction, preventing cerebral vasospasm and vasospasm-associated cerebral infarction.
Clazosentan
Purity: 99.43%
Catalog No. T64084Alias VML 588, Ro 61-1790, AXV-034343Cas No. 180384-56-9
Clazosentan (Ro 61-1790) is a selective antagonist of the endothelin A receptor (ETAreceptor) that inhibits ET-1-mediated vasoconstriction, preventing cerebral vasospasm and vasospasm-associated cerebral infarction.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $84 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $347 | In Stock | |
| 25 mg | $762 | In Stock | |
| 50 mg | $1,230 | In Stock | |
| 100 mg | $1,590 | In Stock |
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Purity:99.43%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Clazosentan (Ro 61-1790) is a selective antagonist of the endothelin A receptor (ETAreceptor) that inhibits ET-1-mediated vasoconstriction, preventing cerebral vasospasm and vasospasm-associated cerebral infarction. |
| In vitro | Clazosentan is an effective competitive antagonist of ET ( A ) receptor-mediated ET-1 and its precursor large ET-1 on cerebral vasoconstriction[2]. |
| In vivo | In Rats, Clazosentan ( 10 μM, 0.05 mL / kg ; intracisternal injection ) Inhibited the contractile responses to ET-1, without preventing SAH-induced upregulation of ET receptors in cerebral arteries[2]. |
| Alias | VML 588, Ro 61-1790, AXV-034343 |
| Molecular Weight | 577.57 |
| Formula | C25H23N9O6S |
| Cas No. | 180384-56-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (103.88 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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