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W146
🥰Excellent
Catalog No. T13327Cas No. 909725-61-7
Alias W-146, W 146
W146 is a selective and potent Sphingosine 1-phosphate receptor subtype 1 (S1PR1) antagonist that induces significant but transient hematolymphopenia in mice.W146 induces significant but transient hematolymphopenia in mice, inducing pulmonary edema.
W146
🥰Excellent
Catalog No. T13327Alias W-146, W 146Cas No. 909725-61-7
W146 is a selective and potent Sphingosine 1-phosphate receptor subtype 1 (S1PR1) antagonist that induces significant but transient hematolymphopenia in mice.W146 induces significant but transient hematolymphopenia in mice, inducing pulmonary edema.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $165 | In Stock | |
| 5 mg | $622 | In Stock | |
| 10 mg | $1,062 | In Stock | |
| 25 mg | $2,125 | In Stock | |
| 50 mg | $3,280 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | W146 is a selective and potent Sphingosine 1-phosphate receptor subtype 1 (S1PR1) antagonist that induces significant but transient hematolymphopenia in mice.W146 induces significant but transient hematolymphopenia in mice, inducing pulmonary edema. |
| Targets&IC50 | S1PR1:70-80 nM(Ki) |
| In vitro | W146 is an antagonist of S1PR1 (Ki: 70-80 nM). [1] W146 pretreatment significantly increased the TUNEL labeling index of endothelial progenitor cells (EPCs) compared with the S1P-treated group. W146 pretreatment significantly increased the level of activated cleaved caspase-3. S1P was able to reduce apoptosis in EPCs, but this protective effect was completely lost after W146 treatment. [2] |
| In vivo | In mice, Injections of W146, W140, JTE013, or Cay10444 do not alter the basal WBC count. when mice are pretreated with W146, it is found that a significant increase in KSL-HSPC mobilization, compared to that in mice pretreated with dextran followed by AMD3100 administration. Moreover, pre-treatment of W146 shows an approximately 8-fold increase of KSL-HSPC mobilization, measured by the CFU-G/M colony-forming assays, compared to that in mice treated with AMD3100 alone. [3] |
| Alias | W-146, W 146 |
| Molecular Weight | 342.37 |
| Formula | C16H27N2O4P |
| Cas No. | 909725-61-7 |
| Smiles | N(C([C@@H](CCP(=O)(O)O)N)=O)C1=CC(CCCCCC)=CC=C1 |
| Relative Density. | 1.233 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 15 mg/mL(43.81 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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