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Iroxanadine
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Iroxanadine
Catalog No. T27627Cas No. 203805-20-3
Iroxanadine (BRX-005) is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation in guinea pig pulmonary artery preparations precontracted with phenylephrine.CAS 번호13480-84-5
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $146 | In Stock | |
| 5 mg | $350 | In Stock | |
| 10 mg | $530 | In Stock | |
| 25 mg | $859 | In Stock | |
| 50 mg | $1,180 | In Stock | |
| 100 mg | $1,590 | In Stock | |
| 500 mg | $3,190 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Iroxanadine (BRX-005) is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation in guinea pig pulmonary artery preparations precontracted with phenylephrine.CAS 번호13480-84-5 |
| In vivo | Iroxanadine improves the survival of vascular endothelial cells (ECs) following ischemia/reperfusion stress. ECs cultured from human umbilical veins were exposed to hypoxia/reoxygenation to mimic ischemia/reperfusion. Caspase activation and apoptosis were monitored in the reoxygenated cells. The addition of Iroxanadine (0.1-1 μM) to the culture medium prior to hypoxia or at the start of reoxygenation significantly reduced the caspase-dependent apoptosis.[1] |
| Alias | BRX005, BRX-235, BRX-005, BRX235, BRX 005, BRX 235 |
| Molecular Weight | 260.33 |
| Formula | C14H20N4O |
| Cas No. | 203805-20-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (172.86 mM)  | |||||||||||||||||||||||||||||||||||
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