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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $69 | In Stock | |
5 mg | $172 | In Stock | |
10 mg | $273 | In Stock | |
25 mg | $451 | In Stock | |
50 mg | $636 | In Stock | |
100 mg | $858 | In Stock | |
500 mg | $1,710 | In Stock | |
1 mL x 10 mM (in DMSO) | $190 | In Stock |
Description | TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors. |
In vitro | TAK-615 specifically binds to membranes expressing the human LPA1 receptor with high affinity (Kd = 1.7 ± 0.5 nM) and low affinity (Kd = 14.5 ± 12.1 nM). TAK-615 partially inhibits the LPA response (~40% at 10 μM, IC50 = 23 ± 13 nM in β-arrestin assay; 60% at 10 μM, IC50 = 91 ± 30 nM in calcium mobilization assay). [1] |
Molecular Weight | 419.44 |
Formula | C25H22FNO4 |
Cas No. | 1664335-55-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 120 mg/mL (286.10 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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