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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $123 | In Stock | |
5 mg | $297 | In Stock | |
10 mg | $455 | In Stock | |
25 mg | $747 | In Stock | |
50 mg | $987 | In Stock | |
100 mg | $1,360 | In Stock | |
1 mL x 10 mM (in DMSO) | $327 | In Stock |
Description | Radioprotectin-1 is a selective agonist of LPA2 with EC50 of 25 nM for murine LPA2 GPCR and exerts radioprotective and radiomitigative action. |
In vitro | In MEF and IEC-6 cells expressing LPA2, Radioprotectin-1 (0, 0.1, 0.3, 1.0, and 3 μM) effectively reduces apoptosis induced by gamma-irradiation and the radiomimetic chemotherapeutic Adriamycin[1]. |
In vivo | In C57BL/6 female mice, Radioprotectin-1 (0.1 and 0.3 mg/kg; s.c.) decreases the mortality in models of the hematopoietic and gastrointestinal acute radiation syndrome[1]. |
Alias | 5-chloro-2-[4-(1,3-dioxobenzo[de]isoquinolin-2-yl)butylsulfamoyl]benzoic acid |
Molecular Weight | 486.92 |
Formula | C23H19ClN2O6S |
Cas No. | 1622006-09-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (205.4 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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