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LPA1 receptor antagonist 1
🥰Excellent
Catalog No. T15785Cas No. 1396006-71-5
Alias LPA1 R antagonist 1
LPA1 receptor antagonist 1(LPA1 R antagonist 1) is a selective and potent lysophosphatidic acid (LPA1) receptor antagonist (IC50 : 25 nM) for the study of idiopathic pulmonary fibrosis.
LPA1 receptor antagonist 1
🥰Excellent
Purity: 99.58%
Catalog No. T15785Alias LPA1 R antagonist 1Cas No. 1396006-71-5
LPA1 receptor antagonist 1(LPA1 R antagonist 1) is a selective and potent lysophosphatidic acid (LPA1) receptor antagonist (IC50 : 25 nM) for the study of idiopathic pulmonary fibrosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $147 | In Stock | |
| 5 mg | $367 | In Stock | |
| 10 mg | $587 | In Stock | |
| 25 mg | $919 | In Stock | |
| 50 mg | $1,230 | In Stock | |
| 100 mg | $1,670 | In Stock |
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Ki16198
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Ki16198 is an orally available LPA receptor antagonist and is a methyl ester derivative of Ki16425. It inhibits LPA1- and LPA3-induced inositol phosphates with Ki values of 0.34 and 0.93 μM, respectively, and can be used in studies of pancreatic carcinogenesis and metastasis.
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Tetradecyl Phosphonate
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Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors.
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Radioprotectin-1
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Radioprotectin-1 is a selective agonist of LPA2 with EC50 of 25 nM for murine LPA2 GPCR and exerts radioprotective and radiomitigative action.
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UCM-05194
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H2L5186303
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H2L5186303 is an LPA2 antagonist and can be used in studies about asthma treatment.
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Ki16425
Debio 0719
T6108355025-24-0
Ki16425 (Debio 0719) is a competitive, potent, and reversible antagonist to LPA1, LPA2, and LPA3, with Ki values of 0.34 μM, 6.5 μM, and 0.93 μM, respectively.
- $35
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DBIBB
T220701569309-92-7In house
DBIBB is a non-lipid agonist of specific lysophosphatidic acid (LPA2) type 2 G-protein-coupled receptor. It is a potentially active molecule for the treatment of acute radiation syndrome caused by high intensity gamma rays on hematopoietic and gastrointestinal systems. It is an intermediate in organic synthesis and drug research. DBIBB can be used to prepare various compounds that reduce gastrointestinal radiation syndrome, increase intestinal crypt survival and intestinal cell proliferation, and reduce cell apoptosis.
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AM966
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LPA2 antagonist 2
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LPA2 antagonist 2 is a selective and potent LPA2 antagonist (IC50: 28.3 nM) with potential anticancer activity, inhibits LPA3, and can be used in the study of cancer.
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GRI977143
GRI 977143
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GRI977143 is a selective and non-lipid agonist of LPA2 (EC50 = 3.3 μM). GRI977143 inhibits the activation of caspases 3, 7, 8, and 9 and and reduces DNA fragmentation.
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TAK-615
T96991664335-55-0
TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.
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H2L 5765834
T22834420841-84-5
H2L 5765834 is a lysophosphatidic acid receptors antagonist
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Purity:99.58%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | LPA1 receptor antagonist 1(LPA1 R antagonist 1) is a selective and potent lysophosphatidic acid (LPA1) receptor antagonist (IC50 : 25 nM) for the study of idiopathic pulmonary fibrosis. |
| Targets&IC50 | LPA1:25 nM |
| In vitro | Compared to Ki16425 and AM095, LPA1 receptor antagonist 1 demonstrates superior anti-proliferative activity. It exhibits the highest selectivity for LPA1 and efficiently inhibits LPA-induced NHLF proliferation and contraction[1]. Similarly, LPA1 receptor antagonist 1 (compound 2) shows highly specific inhibitory activity against LPA1, with minimal inhibition of LPA3 even at relatively high concentrations.[1]. |
| In vivo | Oral administration of LPA1 receptor antagonist 1 (compound 2) to mice led to a dose-dependent reduction in plasma histamine levels in a murine LPA challenge model [1]. |
| Alias | LPA1 R antagonist 1 |
| Molecular Weight | 482.53 |
| Formula | C28H26N4O4 |
| Cas No. | 1396006-71-5 |
| Smiles | C(O)(=O)C1(CC1)C2=CC=C(C=C2)C3=CC=C(C=C3)N4C(NC(O[C@H](C)C5=CC=CC=C5)=O)=C(C)N=N4 |
| Relative Density. | 1.31 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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