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BI 1015550
🥰Excellent
Catalog No. T72031Cas No. 1423719-30-5
Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM. BI 1015550 has potential applications in inflammation, allergic diseases, pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) with a good safety profile.
BI 1015550
🥰Excellent
Purity: 100%
Catalog No. T72031Cas No. 1423719-30-5
Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM. BI 1015550 has potential applications in inflammation, allergic diseases, pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) with a good safety profile.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $59 | In Stock | |
| 5 mg | $127 | In Stock | |
| 10 mg | $197 | In Stock | |
| 25 mg | $397 | In Stock | |
| 50 mg | $589 | In Stock | |
| 100 mg | $843 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM. BI 1015550 has potential applications in inflammation, allergic diseases, pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) with a good safety profile. |
| Targets&IC50 | PDE4B:7.2 nM |
| In vitro | METHODS: Rats were treated with Nerandomilast (BI 1015550) (0.0001-100mM) to study its effect on LPS-stimulated TNF-α release in rat whole blood. RESULTS BI 1015550 completely inhibited TNF-α release in rat whole blood with an IC50 value of 91 nM; high concentrations of BI 1015550 resulted in a concentration-dependent four-fold increase in IL-6 in rats. [1] |
| In vivo | METHODS: Rats were treated with Nerandomilast (BI 1015550) (0.01, 0.1, 1, 3 mg/kg, oral) to study its effect on LPS-stimulated TNF-α release in rat whole blood. RESULTS BI 1015550 at a dose of 3 mg/kg inhibited 93% of TNF-α release. The final experimental result showed that the dose of BI 1015550 that caused half-maximal inhibition (ED50) of LPS-induced TNF-α release was 0.04 mg/kg. [1] |
| Molecular Weight | 448.97 |
| Formula | C20H25ClN6O2S |
| Cas No. | 1423719-30-5 |
| Smiles | N(C1=C2C(=NC(=N1)N3CCC(CC3)C=4N=CC(Cl)=CN4)CCS2=O)C5(CO)CCC5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.49 mg/mL (10 mM)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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