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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $80 | In Stock | |
5 mg | $213 | In Stock | |
10 mg | $347 | In Stock | |
25 mg | $577 | In Stock | |
50 mg | $823 | In Stock | |
100 mg | $1,090 | In Stock | |
1 mL x 10 mM (in DMSO) | $288 | In Stock |
Description | BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2. |
Targets&IC50 | ETA receptor:7.3 nM |
In vitro | In porcine aortic vascular smooth muscle cells, BQ-123 selectively inhibits ETA-mediated contraction. [1] In rat vascular smooth muscle cells, BQ-123 inhibits endothelin-1-induced phosphoinositide breakdown and DNA synthesis. [2] |
In vivo | In rats, BQ-123 (1 mg/kg, i.v.) ameliorates myocardial ischemic-reperfusion injury. [3] In rats with pentylenetetrazole (PTZ)-induced tonic-clonic seizures, BQ-123 (3 mg/kg, i.v.) potently impedes the formation and spread of seizure. [4] In pregnant C57BL/6 mice, BQ-123 (6.7 mg/kg, i.p.) prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. [5] |
Alias | BQ123 |
Molecular Weight | 610.7 |
Formula | C31H42N6O7 |
Cas No. | 136553-81-6 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 12 mg/mL (19.6 mM) DMSO: 93 mg/mL (152.3 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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