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JNJ-49095397
🥰Excellent
Catalog No. T72918Cas No. 1220626-82-3
Alias RV568
JNJ-49095397 (RV568) is a selective p38 MAPK-α and p38 MAPK--γ kinase inhibitor with anti-inflammatory activity and potential antiviral activity for chronic obstructive pulmonary disease (COPD), cystic fibrosis, and respiratory syncytial virus infection.
JNJ-49095397
🥰Excellent
Purity: 100%
Catalog No. T72918Alias RV568Cas No. 1220626-82-3
JNJ-49095397 (RV568) is a selective p38 MAPK-α and p38 MAPK--γ kinase inhibitor with anti-inflammatory activity and potential antiviral activity for chronic obstructive pulmonary disease (COPD), cystic fibrosis, and respiratory syncytial virus infection.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $88 | In Stock | |
| 5 mg | $213 | In Stock | |
| 10 mg | $347 | In Stock | |
| 25 mg | $695 | In Stock | |
| 50 mg | $1,090 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | JNJ-49095397 (RV568) is a selective p38 MAPK-α and p38 MAPK--γ kinase inhibitor with anti-inflammatory activity and potential antiviral activity for chronic obstructive pulmonary disease (COPD), cystic fibrosis, and respiratory syncytial virus infection. |
| In vitro | JNJ-49095397 (1 μg-1 g/mL; 4 h) demonstrates potent anti-inflammatory effects in monocytes and macrophages. When used in combination with corticosteroids, it exhibits synergistic anti-inflammatory effects in poly I:C-stimulated BEAS-2B cells and cigarette smoke models[1]. |
| In vivo | In non-fasted Balb/c mice, in the LPS-induced neutrophil accumulation model, JNJ-49095397 (1, 4, and 20 μg/mouse; intratracheal administration, 2, 8, or 12 h prior to LPS inhalation) prevented the accumulation of neutrophils in the BAL fluid. Significant inhibition of neutrophil accumulation was observed when administered up to 8 h prior to LPS inhalation[1]. |
| Alias | RV568 |
| Molecular Weight | 592.69 |
| Formula | C34H36N6O4 |
| Cas No. | 1220626-82-3 |
| Smiles | O=C(NC1=CC=C(OCC=2C=CN=C(C2)NC(=O)COC)C=3C=CC=CC13)NC4=CC(=NN4C5=CC=C(C=C5)C)C(C)(C)C |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (134.98 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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