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NTP42

🥰Excellent
Catalog No. T12268Cas No. 2055599-51-2

NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)

NTP42

NTP42

🥰Excellent
Purity: 99.09%
Catalog No. T12268Cas No. 2055599-51-2
NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)
Pack SizePriceAvailabilityQuantity
1 mg$57In Stock
2 mg$83In Stock
5 mg$143In Stock
10 mg$226In Stock
25 mg$383In Stock
50 mg$569In Stock
100 mg$816In Stock
1 mL x 10 mM (in DMSO)$162In Stock
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Purity:99.09%
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Product Introduction

Bioactivity
Description
NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)
In vivo
From haemodynamic assessments, NTP42 reduced the MCT-induced PAH, including mean pulmonary arterial pressure (mPAP) and right systolic ventricular pressure (RSVP), being at least comparable to the standard-of-care drugs Sildenafil or Selexipag in bringing about these effects.?Moreover, NTP42 was superior to Sildenafil and Selexipag in significantly reducing pulmonary vascular remodelling, inflammatory mast cell infiltration and fibrosis in MCT-treated animals[1].
Chemical Properties
Molecular Weight515.53
FormulaC25H23F2N3O5S
Cas No.2055599-51-2
SmilesCC(C)(C)NC(=O)NS(=O)(=O)c1cc(ccc1Oc1cccc(c1)-c1ccc(OC(F)F)cc1)C#N
Relative Density.1.39 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (58.19 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9398 mL9.6988 mL19.3975 mL96.9876 mL
5 mM0.3880 mL1.9398 mL3.8795 mL19.3975 mL
10 mM0.1940 mL0.9699 mL1.9398 mL9.6988 mL
20 mM0.0970 mL0.4849 mL0.9699 mL4.8494 mL
50 mM0.0388 mL0.1940 mL0.3880 mL1.9398 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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