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NTP42
Catalog No. T12268Cas No. 2055599-51-2
NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $57 | In Stock | |
| 2 mg | $83 | In Stock | |
| 5 mg | $143 | In Stock | |
| 10 mg | $226 | In Stock | |
| 25 mg | $383 | In Stock | |
| 50 mg | $569 | In Stock | |
| 100 mg | $816 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $162 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM) |
| In vivo | From haemodynamic assessments, NTP42 reduced the MCT-induced PAH, including mean pulmonary arterial pressure (mPAP) and right systolic ventricular pressure (RSVP), being at least comparable to the standard-of-care drugs Sildenafil or Selexipag in bringing about these effects.?Moreover, NTP42 was superior to Sildenafil and Selexipag in significantly reducing pulmonary vascular remodelling, inflammatory mast cell infiltration and fibrosis in MCT-treated animals[1]. |
| Molecular Weight | 515.53 |
| Formula | C25H23F2N3O5S |
| Cas No. | 2055599-51-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (58.19 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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