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Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $42 | In Stock | |
2 mg | $59 | In Stock | |
5 mg | $98 | In Stock | |
10 mg | $147 | In Stock | |
25 mg | $263 | In Stock | |
50 mg | $347 | In Stock | |
100 mg | $553 | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension. |
In vivo | GB002 dose- and time-dependently induces lung BMPR2 protein expression.GB002-mediated inhibition of lung PDGFRα/β phosphorylation in healthy Sprague Dawley rats immediately post inhalation[1]. |
Alias | GB002 |
Molecular Weight | 469.54 |
Formula | C27H27N5O3 |
Cas No. | 1619931-27-9 |
Smiles | COc1ccc(cc1OC)-c1cncc(N[C@@H](C)c2cccc(NC(=O)c3cncc(C)c3)c2)n1 |
Relative Density. | 1.252 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (212.98 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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