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SB 452533
🥰Excellent
Catalog No. T23322Cas No. 459429-39-1
SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).
SB 452533
🥰Excellent
Purity: 98.52%
Catalog No. T23322Cas No. 459429-39-1
SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $35 | In Stock | |
| 5 mg | $58 | In Stock | |
| 10 mg | $98 | In Stock | |
| 25 mg | $193 | In Stock | |
| 50 mg | $298 | In Stock | |
| 100 mg | $433 | In Stock | |
| 200 mg | $616 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $77 | In Stock |
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CitedSelect Batch
Purity:98.52%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8). |
| Targets&IC50 | TRPV1:7.8(pKb) |
| In vitro | SB 452533 significantly reduced Capsaicin-induced phosphorylation of AMPK and CAMKK2[1]. |
| In vivo | Small dose Cap significantly reduced bleomycin-induced pulmonary fibrosis in mice and obviously reversed alveolar epithelial cells epithelial-mesenchymal transition (EMT) (the expression of E-cadherin and ZO-1 were increased(P＜0.05 or P＜0.01)and the expression of α-SMA and Vimentin were decreased (P＜0.05 or P＜0.01) after drugs treatment for 21 day, concomitantly with the increase the expressions of TRPV1 and CGRP (P＜0.05 or P＜0.01), and inhibiting ERK1/2 phosphorylation and eIF3a expression (P＜0.05 or P＜0.01). These effects of small dose Cap were abolished in the presence of TRPV1 receptor antagonist SB 452533[2]. |
| Molecular Weight | 376.29 |
| Formula | C18H22BrN3O |
| Cas No. | 459429-39-1 |
| Smiles | CCN(CCNC(=O)Nc1ccccc1Br)c1cccc(C)c1 |
| Relative Density. | 1.347 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 60 mg/mL (159.45 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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