Shopping Cart

Remove All

Your shopping cart is currently empty

Brilaroxazine

Select Batch

Purity:98%

Resource Download

COA HPLC HNMR

Brilaroxazine

Catalog No. T14782Cas No. 1239729-06-6

Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-HT2B, and 5-HT7 receptors with Kis of 0.19 nM and 2.7 nM, respectively. Brilaroxazine can be used for research about cognitive impairments in neuropsychiatric and neurological diseases.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$107	In Stock
5 mg	$263	In Stock
10 mg	$428	In Stock
25 mg	$737	In Stock
50 mg	$1,060	In Stock
100 mg	$1,450	In Stock
500 mg	$2,880	In Stock
1 mL x 10 mM (in DMSO)	$387	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "Brilaroxazine"

Product Introduction

Bioactivity

Description	Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-HT2B, and 5-HT7 receptors with Kis of 0.19 nM and 2.7 nM, respectively. Brilaroxazine can be used for research about cognitive impairments in neuropsychiatric and neurological diseases.
In vivo	Brilaroxazine (10 mg/kg) had efficacy in PAH, and mitigated the functional and structural effects of MCT-induced PAH, with significant improvements in pulmonary hemodynamics, right ventricular (RV) hypertrophy, SO2, and pulmonary blood vessel structural changes[3].
Alias	RP5063

Chemical Properties

Molecular Weight	450.36
Formula	C22H25Cl2N3O3
Cas No.	1239729-06-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (210.94 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2204 mL	11.1022 mL	22.2045 mL	111.0223 mL
5 mM	0.4441 mL	2.2204 mL	4.4409 mL	22.2045 mL
10 mM	0.2220 mL	1.1102 mL	2.2204 mL	11.1022 mL
20 mM	0.1110 mL	0.5551 mL	1.1102 mL	5.5511 mL
50 mM	0.0444 mL	0.2220 mL	0.4441 mL	2.2204 mL
100 mM	0.0222 mL	0.1110 mL	0.2220 mL	1.1102 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Welcome to our new website experience

What's new

Brilaroxazine

Brilaroxazine