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Sulmazole

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Purity:99.64%

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COA HNMR HPLC LCMS

Sulmazole

Catalog No. T28881Cas No. 73384-60-8

Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.Sulmazole has been shown to improve cardiac index, low pulmonary capillary wedge pressure, and can be used in the study of heart failure.Sulmazole is a small molecule cGMP-PDE inhibitor.

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Pack Size	Price	Availability
1 mg	$32	In Stock
5 mg	$72	In Stock
10 mg	$106	In Stock
25 mg	$178	In Stock
50 mg	$266	In Stock
100 mg	$397	In Stock
500 mg	$945	In Stock

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Product Introduction

Bioactivity

Description	Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.Sulmazole has been shown to improve cardiac index, low pulmonary capillary wedge pressure, and can be used in the study of heart failure.Sulmazole is a small molecule cGMP-PDE inhibitor.
In vitro	In cell-free biochemical assays, observed activities of sulmazole are cyclic nucleotide phosphodiesterase inhibitors with similar potencies and selectivities for the Type III enzyme (IC50=5.0 +/- 1.9 X 10(-5) M). sulmazole had little or no effects on sarcolemmal Na+/K+-ATPase, Ca2+ ATPase or Na+/Ca2+ exchange, and sulmazole had a small, stimulatory effect on myofibrillar ATPase.[2]
In vivo	In anaesthetized guinea pigs and dogs, bolus i.v. injections of sulmazole (0.1-10.0 mg kg-1) caused a significant, dose-related increase in ventricular dP/dt, and a reduction in diastolic blood pressure, with small increases in heart rate.[1]
Alias	Vardax, AR-L 115BS, AR-L 115-BS

Chemical Properties

Molecular Weight	287.34
Formula	C14H13N3O2S
Cas No.	73384-60-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6.25 mg/mL (21.75 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4802 mL	17.4010 mL	34.8020 mL	174.0099 mL
5 mM	0.6960 mL	3.4802 mL	6.9604 mL	34.8020 mL
10 mM	0.3480 mL	1.7401 mL	3.4802 mL	17.4010 mL
20 mM	0.1740 mL	0.8700 mL	1.7401 mL	8.7005 mL

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