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Lonidamine
🥰Excellent
Catalog No. T0239Cas No. 50264-69-2
Alias Diclondazolic Acid, DICA, AF1890
Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).
Lonidamine
🥰Excellent
Purity: 97.36%
Catalog No. T0239Alias Diclondazolic Acid, DICA, AF1890Cas No. 50264-69-2
Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $33 | In Stock | |
| 5 mg | $45 | In Stock | |
| 10 mg | $58 | In Stock | |
| 25 mg | $75 | In Stock | |
| 50 mg | $117 | In Stock | |
| 100 mg | $152 | In Stock | |
| 500 mg | $373 | In Stock | |
| 1 g | $555 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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CitedSelect Batch
Purity:97.36%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK). |
| Targets&IC50 | Mitochondrial pyruvate carrier:2.5 μM (Ki) |
| In vitro | In mice carrying glioma tumors, Lonidamine (160 mg/kg) effectively reduced tumor growth. |
| In vivo | In both normal and tumor cells, Lonidamine reduces oxygen consumption while augmenting aerobic glycolysis in normal cells, thereby inhibiting aerobic glycolysis in tumor cells. The compound induces apoptosis at a concentration of 50 mg/ml in resistant cell lines, including the human breast cancer cell line MCF-7 ADR(r) and the LB9 multiform glioblastoma cell line, which exhibit resistance to doxorubicin and nitrosourea. |
| Alias | Diclondazolic Acid, DICA, AF1890 |
| Molecular Weight | 321.16 |
| Formula | C15H10Cl2N2O2 |
| Cas No. | 50264-69-2 |
| Smiles | OC(=O)c1nn(Cc2ccc(Cl)cc2Cl)c2ccccc12 |
| Relative Density. | 1.47 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (186.82 mM), Sonication is recommended.  Ethanol: 1.6 mg/mL (5 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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