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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $33 | In Stock | |
5 mg | $45 | In Stock | |
10 mg | $58 | In Stock | |
25 mg | $75 | In Stock | |
50 mg | $117 | In Stock | |
100 mg | $152 | In Stock | |
500 mg | $373 | In Stock | |
1 g | $555 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK). |
Targets&IC50 | Mitochondrial pyruvate carrier:2.5 μM (Ki) |
In vitro | In mice carrying glioma tumors, Lonidamine (160 mg/kg) effectively reduced tumor growth. |
In vivo | In both normal and tumor cells, Lonidamine reduces oxygen consumption while augmenting aerobic glycolysis in normal cells, thereby inhibiting aerobic glycolysis in tumor cells. The compound induces apoptosis at a concentration of 50 mg/ml in resistant cell lines, including the human breast cancer cell line MCF-7 ADR(r) and the LB9 multiform glioblastoma cell line, which exhibit resistance to doxorubicin and nitrosourea. |
Alias | AF1890, DICA, Diclondazolic Acid |
Molecular Weight | 321.16 |
Formula | C15H10Cl2N2O2 |
Cas No. | 50264-69-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (186.82 mM), Sonication is recommended. ![]() Ethanol: 1.6 mg/mL (5 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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