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SCH 563705 is an orally available and highly potent CXCR2 and CXCR1 antagonist for the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $329 | In Stock | |
5 mg | $787 | In Stock | |
10 mg | $1,230 | In Stock | |
25 mg | $1,830 | In Stock | |
50 mg | $2,480 | In Stock | |
1 mL x 10 mM (in DMSO) | $883 | In Stock |
Description | SCH 563705 is an orally available and highly potent CXCR2 and CXCR1 antagonist for the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation. |
Targets&IC50 | CXCR2:1 nM (ki), CXCR2:1.3 nM, CXCR2 (mouse):5.2 nM, CXCR1:7.3 nM, CXCR1:3 nM (ki) |
In vitro | SCH 563705 is a potent oral CXCR2 and CXCR1 antagonist with IC50 values of CXCR2 IC50=1.3 nM, CXCR1 IC50=7.3 nM, and Ki values of CXCR2 Ki=1 nM and CXCR1 Ki=3 nM, respectively.SCH 563705 potently inhibits Gro-a and IL-8 induced human neutrophil migration (CXCR2 IC50=0.5 nM, CXCR1 IC50=37 nM). SCH 563705 effectively inhibited Gro-a and IL-8-induced human neutrophil migration (CXCR2 IC50=0.5 nM, CXCR1 IC50=37 nM). [1] SCH 563705 effectively inhibits mouse CXCR2 (IC50 = 5.2 nM). [2] |
In vivo | SCH 563705 has a favorable oral pharmacokinetic profile in rats, mice, monkeys and dogs. [1] Oral administration of 50 mg/kg SCH 563705 to BALB/c female mice decreased the frequency of Ly6G+ Ly6C+ neutrophils in the blood and maintained the level of Ly6GLy6C hi monocytes. [2] |
Molecular Weight | 425.48 |
Formula | C23H27N3O5 |
Cas No. | 473728-58-4 |
Smiles | N(C1=C(N[C@H](CC)C2=CC(C(C)C)=CO2)C(=O)C1=O)C3=C(O)C(C(N(C)C)=O)=CC=C3 |
Relative Density. | 1.29g/cm3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (235.03 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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