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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $483 | In Stock | |
10 mg | $692 | In Stock | |
25 mg | $1,080 | In Stock | |
50 mg | $1,490 | In Stock | |
100 mg | $1,970 | In Stock |
Description | CXCL-CXCR1/2-IN-1 is an orally active and potent inhibitor of the ELR+CXCL-CXCR1/2 pathway with anticancer and anti-angiogenic activity and can be used to study cardiovascular disease and cancer. |
In vitro | CXCL-CXCR1/2-IN-1 (compound 10; 1-2.5 μM; 24-48h; A498 cells) showed reduced ERK and AKT phosphorylation in A498 cells. CXCL-CXCR1/2-IN-1 also can inhibit the secretion of CXCL1, CXCL5, and CXCL8, which are representative pro-angiogenic ELR+CXCL cytokines.[1] |
In vivo | CXCL-CXCR1/2-IN-1 (1 μM; 48h; Female NOD SCID mice injected with 786 RCC cells) reduces the metastatic area in zebrafish embryos injected with A498 cells.[1] CXCL-CXCR1/2-IN-1 (100 mg/kg; oral gavage; twice a day; for 28 days) inhibits tumor growth in mice.[1] |
Molecular Weight | 383.21 |
Formula | C14H8Cl2N4O3S |
Cas No. | 2415653-55-1 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
Solubility Information | DMSO: 2 mg/mL (5.22 mM) | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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