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Talniflumate
🥰Excellent
Catalog No. T4503Cas No. 66898-62-2
Alias Somalgen
Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.
Talniflumate
🥰Excellent
Purity: 99.81%
Catalog No. T4503Alias SomalgenCas No. 66898-62-2
Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 29 € | In Stock | |
| 2 mg | 41 € | In Stock | |
| 5 mg | 66 € | In Stock | |
| 10 mg | 93 € | In Stock | |
| 25 mg | 182 € | In Stock | |
| 50 mg | 300 € | In Stock | |
| 100 mg | 449 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 73 € | In Stock |
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Purity:99.81%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome. |
| Alias | Somalgen |
| Molecular Weight | 414.33 |
| Formula | C21H13F3N2O4 |
| Cas No. | 66898-62-2 |
| Smiles | O(C(=O)C1=C(NC2=CC(C(F)(F)F)=CC=C2)N=CC=C1)C3C=4C(C(=O)O3)=CC=CC4 |
| Relative Density. | 1.49 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (24.14 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
ulcerogenicTalniflumatepulmonaryobstructiveNAcetylglucosaminyltransferaseIntestinal diseaseInhibitorinhibithCLCA1/mCLCA3GCNT3cystic fibrosisCOXCOPDCl? ChannelsCl-/HCO3- exchangerchronicChloridechannelChloride ChannelChloride channelBA 7602-06asthmaanti-inflammatoryAnionExchangerAnion Exchangeranalgesic
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