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Doxapram
🥰Excellent
Catalog No. T22315Cas No. 309-29-5
Alias Dopram
Doxapram (Dopram) is a respiratory stimulant that inhibits TASK-1, TASK-3, and TASK-1/TASK-3 heterodimer channels and is used to study ventilatory failure caused by apnea of ​​prematurity and exacerbation of chronic obstructive pulmonary disease.
Doxapram
🥰Excellent
Catalog No. T22315Alias DopramCas No. 309-29-5
Doxapram (Dopram) is a respiratory stimulant that inhibits TASK-1, TASK-3, and TASK-1/TASK-3 heterodimer channels and is used to study ventilatory failure caused by apnea of ​​prematurity and exacerbation of chronic obstructive pulmonary disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $36 | In Stock | |
| 5 mg | $76 | In Stock | |
| 10 mg | $109 | In Stock | |
| 25 mg | $179 | In Stock | |
| 50 mg | $263 | In Stock | |
| 100 mg | $388 | In Stock | |
| 200 mg | $578 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Doxapram (Dopram) is a respiratory stimulant that inhibits TASK-1, TASK-3, and TASK-1/TASK-3 heterodimer channels and is used to study ventilatory failure caused by apnea of ​​prematurity and exacerbation of chronic obstructive pulmonary disease. |
| Targets&IC50 | TASK3:37 μM (EC50), TASK1:410 nM (EC50), TASK1/TASK3:9 μM (EC50), K+ currents recorded in type I cells:13 mM |
| In vitro | Doxapram inhibits TASK-1 (EC50=410 nM), TASK-3 (EC50=37 μM), TASK-1/TASK-3 (EC50=9 μM) heterodimeric channel function. Doxapram also evoked 3H overflow in a concentration dependent manner, and Doxapram-evoked release was inhibited by the Ca2+ channel blocker nifedipine (5 mM). [1] Doxapram (1-100 mM) caused rapid, reversible and dose-dependent inhibitions of K+ currents recorded in type I cells (IC50=13 mM). Doxapram was also seen to directly inhibit Ca(2+)-independent K+ currents. Doxapram was a more potent inhibitor of the Ca(2+)-activated K+ currents recorded under control conditions. [2] |
| Alias | Dopram |
| Molecular Weight | 378.51 |
| Formula | C24H30N2O2 |
| Cas No. | 309-29-5 |
| Smiles | O=C1N(CC)CC(CCN2CCOCC2)C1(C=3C=CC=CC3)C=4C=CC=CC4 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 50 mg/mL, (132.10 mM.), Sonication is recommended. DMSO: 50 mg/mL, (132.10 mM.), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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