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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $34 | In Stock | |
5 mg | $77 | In Stock | |
10 mg | $123 | In Stock | |
25 mg | $222 | In Stock | |
50 mg | $333 | In Stock | |
100 mg | $492 | In Stock | |
500 mg | $1,080 | In Stock | |
1 mL x 10 mM (in DMSO) | $85 | In Stock |
Description | Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be beneficial in the treatment of conditions with unbalanced pulmonary neutrophilia. |
In vitro | Navarixin is a potent, allosteric antagonist of both CXCR1 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly[1]. |
Alias | MK-7123, SCH 527123 |
Molecular Weight | 397.42 |
Formula | C21H23N3O5 |
Cas No. | 473727-83-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (138.39 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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