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SR144528
🥰Excellent
Catalog No. T16928Cas No. 192703-06-3
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM).
SR144528
🥰Excellent
Purity: 99.6%
Catalog No. T16928Cas No. 192703-06-3
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $36 | In Stock | |
| 5 mg | $87 | In Stock | |
| 10 mg | $157 | In Stock | |
| 25 mg | $357 | In Stock | |
| 50 mg | $533 | In Stock | |
| 100 mg | $769 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $96 | In Stock |
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Purity:99.6%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM). |
| Targets&IC50 | CB2 receptor:0.6 nM(ki) |
| In vitro | SR144528(1 μM) stimulates the forskolin-sensitive adenylyl cyclase activity in CHO-CB2 cells in a concentration-dependent manner with an EC50 of 26 nM[1]. In Raw 264.7 macrophages, SR144528 reduces the activity of caspase 3. SR144528(10 μM) inhibits microsomal ACAT activity(68%)[2]. |
| In vivo | SR144528 enhances delayedgastric emptying[3]. |
| Molecular Weight | 476.05 |
| Formula | C29H34ClN3O |
| Cas No. | 192703-06-3 |
| Smiles | [H][C@@]12CC[C@@](C)(C1)[C@H](NC(=O)c1cc(-c3ccc(Cl)c(C)c3)n(Cc3ccc(C)cc3)n1)C2(C)C |
| Relative Density. | 1.22g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45.0 mg/mL (94.5 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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