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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $52 | 5 days | |
1 mL x 10 mM (in DMSO) | $120 | 5 days |
Description | SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating antagonist of β3-adrenergic receptor(IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively). |
In vitro | In Neuro-2A, BE(2)C and SK-N-BE(2) NB cell lines,SR59230A (100 nM-50 μM; 24 hours) is able to reduce cell viability in a dose-dependent manner [3]. |
In vivo | Slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post-injection produced by MDMA (20 mg/kg) . SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA[4]. |
Molecular Weight | 361.91 |
Formula | C21H28ClNO2 |
Cas No. | 1135278-41-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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