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SRI-41315

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Catalog No. T61306Cas No. 1613509-49-1
Alias SRI41315

SRI-41315 is an eRF1 degrader that acts as a molecular glue at the center of ribosomal decoding.SRI-41315 induces an extended pause at the termination codon and inhibits cystic fibrosis-associated PTC in immortalized and primary human bronchial epithelial cells, restoring CFTR expression and function.SRI-41315 inhibits PTC by decreasing the abundance of the termination factor eRF1 NIOCH 14

SRI-41315

SRI-41315

🥰Excellent
Catalog No. T61306Alias SRI41315Cas No. 1613509-49-1
SRI-41315 is an eRF1 degrader that acts as a molecular glue at the center of ribosomal decoding.SRI-41315 induces an extended pause at the termination codon and inhibits cystic fibrosis-associated PTC in immortalized and primary human bronchial epithelial cells, restoring CFTR expression and function.SRI-41315 inhibits PTC by decreasing the abundance of the termination factor eRF1 NIOCH 14
Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
5 mg$88In Stock
10 mg$143In Stock
25 mg$288In Stock
50 mg$465In Stock
100 mg$759In Stock
200 mg$1,050In Stock
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Product Introduction

Bioactivity
Description
SRI-41315 is an eRF1 degrader that acts as a molecular glue at the center of ribosomal decoding.SRI-41315 induces an extended pause at the termination codon and inhibits cystic fibrosis-associated PTC in immortalized and primary human bronchial epithelial cells, restoring CFTR expression and function.SRI-41315 inhibits PTC by decreasing the abundance of the termination factor eRF1 NIOCH 14
In vitro
SRI-41315 showed target cytotoxicity (CC50) values above 50 µM in both FRT cells and 16HBE14o- cells.[1]
SRI-41315 (5 µM, 20 hr treatment) decreased eRF1 levels via a proteasome-mediated degradation pathway. [1]
AliasSRI41315
Chemical Properties
Molecular Weight357.41
FormulaC22H19N3O2
Cas No.1613509-49-1
SmilesO=C1C=2C=CC=CC2N(C=3N=C(N(C=4C=CC=CC4)C(=O)C13)C5CCC5)C
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 16 mg/mL (44.77 mM), Sonication is recommended
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7979 mL13.9895 mL27.9791 mL139.8954 mL
5 mM0.5596 mL2.7979 mL5.5958 mL27.9791 mL
10 mM0.2798 mL1.3990 mL2.7979 mL13.9895 mL
20 mM0.1399 mL0.6995 mL1.3990 mL6.9948 mL

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