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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $197 | In Stock | |
5 mg | $478 | In Stock | |
10 mg | $654 | In Stock | |
25 mg | $990 | In Stock | |
50 mg | $1,330 | In Stock | |
100 mg | $1,750 | In Stock | |
1 mL x 10 mM (in DMSO) | $478 | In Stock |
Description | VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Modification of CFTR by this small molecule modulator can increase arylsulfatase B (ARSB), which is necessary to reduce the accumulation of sulphate glycosaminosaccharide (gag), thus reducing the accumulation of 4-chondroitin sulfate in cystic fibrosis. |
In vitro | VRT-532 binds directly to G551D-CFTR in isolated systems, thereby improving its channel function and increasing its ATPase rate. VRT-325 decreased the apparent ATP affinity of purified and reconstituted F508del-CFTR[1]. |
Alias | CFpot-532, CFpot-532) |
Molecular Weight | 250.3 |
Formula | C16H14N2O |
Cas No. | 38214-71-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 2.5 mg/mL (27.39 mM) ![]() | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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