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VRT-532

🥰Excellent
Catalog No. T29114Cas No. 38214-71-0
Alias CFpot-532, CFpot532

VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Modification of CFTR by this small molecule modulator can increase arylsulfatase B (ARSB), which is necessary to reduce the accumulation of sulphate glycosaminosaccharide (gag), thus reducing the accumulation of 4-chondroitin sulfate in cystic fibrosis.

VRT-532

VRT-532

🥰Excellent
Purity: 100%
Catalog No. T29114Alias CFpot-532, CFpot532Cas No. 38214-71-0
VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Modification of CFTR by this small molecule modulator can increase arylsulfatase B (ARSB), which is necessary to reduce the accumulation of sulphate glycosaminosaccharide (gag), thus reducing the accumulation of 4-chondroitin sulfate in cystic fibrosis.
Pack SizePriceAvailabilityQuantity
1 mg$95In Stock
5 mg$238In Stock
10 mg$358In Stock
25 mg$592In Stock
50 mg$798In Stock
100 mg$1,050In Stock
200 mg$1,390In Stock
1 mL x 10 mM (in DMSO)$213In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Modification of CFTR by this small molecule modulator can increase arylsulfatase B (ARSB), which is necessary to reduce the accumulation of sulphate glycosaminosaccharide (gag), thus reducing the accumulation of 4-chondroitin sulfate in cystic fibrosis.
In vitro
VRT-532 binds directly to G551D-CFTR in isolated systems, thereby improving its channel function and increasing its ATPase rate. VRT-325 decreased the apparent ATP affinity of purified and reconstituted F508del-CFTR[1].
AliasCFpot-532, CFpot532
Chemical Properties
Molecular Weight250.3
FormulaC16H14N2O
Cas No.38214-71-0
SmilesCC1=CC=C(O)C(=C1)C1=NNC(=C1)C1=CC=CC=C1
Relative Density.1.213 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 2.5 mg/mL (27.39 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.9952 mL19.9760 mL39.9521 mL199.7603 mL
5 mM0.7990 mL3.9952 mL7.9904 mL39.9521 mL
10 mM0.3995 mL1.9976 mL3.9952 mL19.9760 mL
20 mM0.1998 mL0.9988 mL1.9976 mL9.9880 mL

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