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Stapokibart
🥰Excellent
Catalog No. T81098Cas No. 2734715-10-5
Alias CM310, CM 310
Stapokibart (CM310) is a humanized monoclonal antibody targeting IL-4Rα, blocking IL-4Rα-mediated signaling. It is used in studies of atopic dermatitis.
Stapokibart
Stapokibart
🥰Excellent
Purity: 95%
Catalog No. T81098Alias CM310, CM 310Cas No. 2734715-10-5
Stapokibart (CM310) is a humanized monoclonal antibody targeting IL-4Rα, blocking IL-4Rα-mediated signaling. It is used in studies of atopic dermatitis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $247 | In Stock | |
| 5 mg | $619 | In Stock | |
| 10 mg | $993 | In Stock | |
| 25 mg | $1,470 | In Stock | |
| 50 mg | $1,980 | In Stock |
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Concentration:3.81 mg/mL
Purity:95%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Stapokibart (CM310) is a humanized monoclonal antibody targeting IL-4Rα, blocking IL-4Rα-mediated signaling. It is used in studies of atopic dermatitis. |
| In vitro | Stapokibart showed high affinity binding to IL-4Rα in human, cynomophage monkey and rat with equilibrium dissociation constant (KD) values of 0.25, 1.5 and 2.75 nM and IC50 values of 0.40 nM, respectively. In HEK293-STAT6 reporter cells, Stapokibart showed concentration-dependent inhibition of IL-4 - or IL-13-induced STAT6 activation, with IC50 values of 0.039 nM and 0.041 nM, respectively. In TF-1 cells, Stapokibart effectively inhibited IL-4 and IL-13-induced cell proliferation, with IC50 values of 1.75 nM and 0.13 nM, respectively. [1] |
| In vivo | In an OVA-induced asthma model, Stapokibart showed protective effects against IL-4/IL-13 induced airway inflammation in rats. Stapokibart (25, 50, 100 mg/kg) reduces disease severity of OVA-induced rhinitis in rats. [1] |
| Alias | CM310, CM 310 |
| Cas No. | 2734715-10-5 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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