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STK16-IN-1 is an inhibitor of STK16 kinase (IC50: 295 nM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $41 | In Stock | |
25 mg | $92 | In Stock | |
50 mg | $163 | In Stock | |
100 mg | $238 | In Stock | |
1 mL x 10 mM (in DMSO) | $30 | In Stock |
Description | STK16-IN-1 is an inhibitor of STK16 kinase (IC50: 295 nM). |
Targets&IC50 | STK16:295 nM |
In vitro | STK16-IN-1 inhibits mTOR kinase (IC50: 5.56 μM). STK16-IN-1 shows potent inhibitory activity against STK16 kinase (IC50=0.295 μM) with excellent selective across the kinome as assessed using the KinomeScanTM profiling assay. STK16-IN-1 treatment causes a reduction in cell number and accumulation of binucleated cells, which can be recapitulated by RNAi knockdown of STK16 in MCF-7 cells. Co-treatment of STK16-IN-1 with chemotherapeutics such as cisplatin, doxorubicin, colchicine and paclitaxel results in a slight potentiation of the anti-proliferative effects of the chemotherapeutics. STK16-IN-1 provides a useful tool compound for further elucidating the biological functions of STK16) [1]. |
Molecular Weight | 293.3 |
Formula | C17H12FN3O |
Cas No. | 1223001-53-3 |
Smiles | Cc1cc(ccc1F)-n1c2c3ccnc3[nH]cc2ccc1=O |
Relative Density. | 1.38 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (187.52 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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