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SY-640

Catalog No. T37859 CAS 168705-70-2

SY-640 is an Acetamide derivative. SY-640 exhibits potent hepatoprotective effect. SY-640 reduces liver injury in mice induced by Propionibacterium acnes and Lipopolysaccharide.

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SY-640, CAS 168705-70-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 54.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 110.00
50 mg	In stock	$ 158.00
100 mg	In stock	$ 229.00

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Purity: 98.82%

Purity: 97.55%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SY-640 is an Acetamide derivative. SY-640 exhibits potent hepatoprotective effect. SY-640 reduces liver injury in mice induced by Propionibacterium acnes and Lipopolysaccharide.
In vitro	SY-640 attenuates the increased expression of leukocyte function-associated antigen-1 and inhibits the number of liver-infiltrating cells[1].
In vivo	SY-640, administered orally at a dose of 150 mg/kg once daily for three days, significantly elevates both cytochrome P-450 content and aminopyrine demethylase activity in the liver microsomes of mice. However, hepatic microsomal aminopyrine demethylase activity notably decreases two hours post-administration. Furthermore, a seven-day regimen of the same dose markedly reduces liver injury induced by Propionibacterium acnes and Lipopolysaccharide, whereas a single dose proves ineffective.

Molecular Weight	207.23
Formula	C11H13NO3
CAS No.	168705-70-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (458.43 mM)

References and Literature

1. P F Li, et al. [Inhibitory effect of 2-(N-acetyl-methyl amino)-3',4'-methylenedioxyacetyl-aminophene(SY-640) on covalent binding of carcinogenic benzo(a)pyrene with mouse hepatocyte nuclear DNA]. Yao Xue Xue Bao. 1997 Sep;32(9):663-8. 2. Y Tanaka, et al. Hepatoprotective effect of SY-640, a novel acetamide derivative, on Propionibacterium acnes and lipopolysaccharide-induced liver injury in mice. Arch Int Pharmacodyn Ther. Mar-Apr 1995;329(2):319-30.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SY-640 168705-70-2 Metabolism Endogenous Metabolite Acetamide inhibit acnes Propionibacterium hepatoprotective Lipopolysaccharide Inhibitor SY 640 SY640 inhibitor

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