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SY-640
SY-640 is an Acetamide derivative. SY-640 exhibits potent hepatoprotective effect. SY-640 reduces liver injury in mice induced by Propionibacterium acnes and Lipopolysaccharide.
Catalog No. T37859Cas No. 168705-70-2
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Purity:98.82%
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SY-640
Catalog No. T37859Cas No. 168705-70-2
SY-640 is an Acetamide derivative. SY-640 exhibits potent hepatoprotective effect. SY-640 reduces liver injury in mice induced by Propionibacterium acnes and Lipopolysaccharide.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $32 | In Stock | |
| 10 mg | $43 | In Stock | |
| 25 mg | $66 | In Stock | |
| 50 mg | $94 | In Stock | |
| 100 mg | $137 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SY-640 is an Acetamide derivative. SY-640 exhibits potent hepatoprotective effect. SY-640 reduces liver injury in mice induced by Propionibacterium acnes and Lipopolysaccharide. |
| In vitro | SY-640 attenuates the increased expression of leukocyte function-associated antigen-1 and inhibits the number of liver-infiltrating cells[1]. |
| In vivo | SY-640, administered orally at a dose of 150 mg/kg once daily for three days, significantly elevates both cytochrome P-450 content and aminopyrine demethylase activity in the liver microsomes of mice. However, hepatic microsomal aminopyrine demethylase activity notably decreases two hours post-administration. Furthermore, a seven-day regimen of the same dose markedly reduces liver injury induced by Propionibacterium acnes and Lipopolysaccharide, whereas a single dose proves ineffective. |
| Molecular Weight | 207.23 |
| Formula | C11H13NO3 |
| Cas No. | 168705-70-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 95 mg/mL (458.43 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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