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Synucleozid hydrochloride
🥰Excellent
Catalog No. T13049LCas No. 2741856-68-6
Alias Synucleozid hydrochloride (502139-01-7 free base), NSC-377363 hydrochloride, NSC377363 hydrochloride, NSC 377363 hydrochloride
Synucleozid hydrochloride inhibits the translation of the intrinsically disordered protein α-synuclein by targeting its structured mRNA. Synucleozid hydrochloride targets the IRE structure and inhibits SNCA translation in cells, and can be used to study Alzheimer's disease.
Synucleozid hydrochloride
🥰Excellent
Purity: 98.13%
Catalog No. T13049LAlias Synucleozid hydrochloride (502139-01-7 free base), NSC-377363 hydrochloride, NSC377363 hydrochloride, NSC 377363 hydrochlorideCas No. 2741856-68-6
Synucleozid hydrochloride inhibits the translation of the intrinsically disordered protein α-synuclein by targeting its structured mRNA. Synucleozid hydrochloride targets the IRE structure and inhibits SNCA translation in cells, and can be used to study Alzheimer's disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $198 | In Stock |
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Purity:98.13%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Synucleozid hydrochloride inhibits the translation of the intrinsically disordered protein α-synuclein by targeting its structured mRNA. Synucleozid hydrochloride targets the IRE structure and inhibits SNCA translation in cells, and can be used to study Alzheimer's disease. |
| Targets&IC50 | SNCA IRE RNA:1.5 μM |
| In vitro | b>METHODS: The affinity of Synucleozid (100 nM-100 μM) for its putative binding site A in the IRE was measured by using a fluorescent adenine analog to 2-aminopurine (2-AP). RESULTS: Synucleozid reduced 2-AP emission with an EC50 of 2.7 ± 0.4 μM; importantly, restoration of 2-AP emission was observed as a function of the concentration of unlabeled SNCA IRE RNA (RNA-0), providing a competitive Kd value of 1.5 ± 0.3 μM. [1] |
| Alias | Synucleozid hydrochloride (502139-01-7 free base), NSC-377363 hydrochloride, NSC377363 hydrochloride, NSC 377363 hydrochloride |
| Molecular Weight | 404.9 |
| Formula | C22H21ClN6 |
| Cas No. | 2741856-68-6 |
| Smiles | Cl.N=C(N)C1=CC=C(C=C1)NC=2C=CC(=CC2)C3=CC4=CC=C(C=C4N3)C(=N)N |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (246.97 mM), Sonication is recommended. H2O: 1 mg/mL (2.47 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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