keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tat-beclin 1 acetate is a potent inducer of autophagy and interacts with the negative regulator of autophagy, GAPR-1. Tat-beclin 1 acetate decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 122.00 | |
5 mg | In stock | $ 248.00 | |
10 mg | In stock | $ 419.00 | |
25 mg | In stock | $ 697.00 | |
50 mg | In stock | $ 992.00 | |
100 mg | In stock | $ 1,330.00 | |
500 mg | In stock | $ 2,670.00 |
Description | Tat-beclin 1 acetate is a potent inducer of autophagy and interacts with the negative regulator of autophagy, GAPR-1. Tat-beclin 1 acetate decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1). |
In vitro | Tat-beclin 1 acetate (10 μM; 2-4 hours post-infection) decreases the intracellular survival of L. monocytogenes in primary murine bone-marrow-derived macrophages (BMDMs)[1]. Tat-beclin 1 acetate (10, 30, 50 μM; 24 hours) induces autophagy and results in a dose-dependent decrease in amounts of p62, a selective autophagy substrate, and a dose-dependent conversion of the non-lipidated form of LC3, LC3-I, to the lipidated, autophagosome-associated form of LC3, LC3-II, in multiple cell lines and primary murine embryonic fibroblasts (MEFs)[1]. |
In vivo | Tat-beclin 1 acetate reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV). Tat-beclin 1 acetate (15 mg/kg; i.p.) induces autophagy in peripheral tissues in adult mice as well as in the central nervous system of neonatal mice[1]. |
Synonyms | Tat-beclin 1 acetate(1423821-88-8 free base) |
Molecular Weight | N/A |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.00mg/ml
You can also refer to dose conversion for different animals. More
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Tat-beclin 1 acetate Autophagy Microbiology/Virology Proteases/Proteasome HIV Protease Tat beclin 1 acetate Tat-beclin 1 Acetate Tatbeclin 1 acetate Tat-beclin 1 acetate(1423821-88-8 free base) inhibitor inhibit