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TH-Z835
Catalog No. T78661Cas No. 2766209-50-9
TH-Z835 is a mutant-selective KRAS(G12D) inhibitor with an IC50 of 1.6 μM.This compound inhibits mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange.
TH-Z835
Catalog No. T78661Cas No. 2766209-50-9
TH-Z835 is a mutant-selective KRAS(G12D) inhibitor with an IC50 of 1.6 μM.This compound inhibits mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | TH-Z835 is a mutant-selective KRAS(G12D) inhibitor with an IC50 of 1.6 μM.This compound inhibits mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange. |
| Targets&IC50 | KRAS(G12D):1.6 μM |
| In vitro | TH-Z835 reduces pERK levels in PANC-1 cells with an IC50 value less than 2.5 μM [1]. Additionally, TH-Z835 exhibits antiproliferative effects in various non-G12D mutant cancer cell lines, including 4T1 (KRAS(WT)), MIA PaCa-2 (KRAS(G12C)), CFPAC-1 (KRAS(G12V)), and HCT116 (KRAS(G13D)), by decreasing pERK and pAKT levels and inducing apoptosis, indicating off-target effects [1]. |
| In vivo | TH-Z835 (10mg/kg; intraperitoneal injection) reduces tumor volume in a C57BL/6 mouse model. In vivo, TH-Z835 induces apoptosis and inhibits MAPK signaling [1]. |
| Molecular Weight | 498.66 |
| Formula | C30H38N6O |
| Cas No. | 2766209-50-9 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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