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TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $44 | In Stock | |
2 mg | $62 | In Stock | |
5 mg | $97 | In Stock | |
10 mg | $189 | In Stock | |
25 mg | $413 | In Stock | |
50 mg | $618 | In Stock | |
100 mg | $879 | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively. |
Targets&IC50 | GPR39 with Zn2+ (murine):5 nM (EC50), GPR39 with Zn2+ (human):9 nM (EC50), GPR39 without Zn2+ (murine):180 nM (EC50), GPR39 without Zn2+ (human):280 nM (EC50) |
In vitro | Measurements of somatostatin confirms that the GPR39 agonist TM-N1324 increases somatostatin release by 53%. TM-N1324 is found to have promising in vitro ADME properties. TM-N1324 has reasonably good aqueous solubility (65 μM at pH 7.0)[1]. |
Molecular Weight | 397.79 |
Formula | C18H13ClFN7O |
Cas No. | 1144477-35-9 |
Smiles | Cc1nn(c2NC(=O)CC(c12)c1ccc(F)cc1Cl)-c1ncnc2[nH]cnc12 |
Relative Density. | 1.74 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 10 mg/mL (25.14 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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