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TM-N1324

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Catalog No. T17103Cas No. 1144477-35-9

TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively.

TM-N1324

TM-N1324

🥰Excellent
Catalog No. T17103Cas No. 1144477-35-9
TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively.
Pack SizePriceAvailabilityQuantity
1 mg$44In Stock
2 mg$62In Stock
5 mg$97In Stock
10 mg$189In Stock
25 mg$413In Stock
50 mg$618In Stock
100 mg$879In Stock
1 mL x 10 mM (in DMSO)$98In Stock
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Product Introduction

Bioactivity
Description
TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively.
Targets&IC50
GPR39 with Zn2+ (murine):5 nM (EC50), GPR39 with Zn2+ (human):9 nM (EC50), GPR39 without Zn2+ (murine):180 nM (EC50), GPR39 without Zn2+ (human):280 nM (EC50)
In vitro
Measurements of somatostatin confirms that the GPR39 agonist TM-N1324 increases somatostatin release by 53%. TM-N1324 is found to have promising in vitro ADME properties. TM-N1324 has reasonably good aqueous solubility (65 μM at pH 7.0)[1].
Chemical Properties
Molecular Weight397.79
FormulaC18H13ClFN7O
Cas No.1144477-35-9
SmilesCc1nn(c2NC(=O)CC(c12)c1ccc(F)cc1Cl)-c1ncnc2[nH]cnc12
Relative Density.1.74 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mg/mL (25.14 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5139 mL12.5694 mL25.1389 mL125.6945 mL
5 mM0.5028 mL2.5139 mL5.0278 mL25.1389 mL
10 mM0.2514 mL1.2569 mL2.5139 mL12.5694 mL
20 mM0.1257 mL0.6285 mL1.2569 mL6.2847 mL

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