Shopping Cart
- Remove All
Your shopping cart is currently empty
TPC2-A1-P
🥰Excellent
Catalog No. T36806Cas No. 2804595-86-4
TPC2-A1-P is a membrane-permeable two-pore channel 2 (TPC2) agonist that differentially activates two-pore channel 2 (TPC2) and mimics the activation of TPC2 with NAADP and PIP(2). TPC2-A1-P can be used to study neurodegenerative lysosomal storage diseases.
TPC2-A1-P
🥰Excellent
Purity: 98.49%
Catalog No. T36806Cas No. 2804595-86-4
TPC2-A1-P is a membrane-permeable two-pore channel 2 (TPC2) agonist that differentially activates two-pore channel 2 (TPC2) and mimics the activation of TPC2 with NAADP and PIP(2). TPC2-A1-P can be used to study neurodegenerative lysosomal storage diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | In Stock | |
| 5 mg | $249 | In Stock | |
| 10 mg | $415 | In Stock | |
| 25 mg | $789 | In Stock | |
| 50 mg | $1,280 | In Stock | |
| 100 mg | $1,950 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $252 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "TPC2-A1-P"
L-Ascorbic acid sodium salt
Vitamin C sodium salt, Sodium L-ascorbate, Sodium ascorbate, L-Ascorbic acid sodium, (+)-Sodium L-ascorbate
T6674134-03-2
L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
- $30
Size
QTY
L-Ascorbic acid
Cited
Vitamin C, L-Ascorbate, L(+)-Ascorbic acid, Ascorbic acid
T092850-81-7
L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-Ascorbic acid is used in the treatment of scurvy.
- $42
Size
QTY
Cited2-Nitrobenzoic acid
o-Nitrobenzoic acid
T64387552-16-9
2-Nitrobenzoic acid (o-Nitrobenzoic acid) is a antiproliferation agent. 2-Nitrobenzoic acid shows IC50 of 8.3 μM to jurkat cell line expressing T type calcium channel alpha 1H or its splice variant delta 25.
- $34
Size
QTY
Ethyl cinnamate
TN1624103-36-6
Ethyl cinnamate has antifungal, and vasorelaxant effects. Ethyl cinnamate can lead to the damage of cell membrane system and metabolic disorder through inducing lipid peroxidation via initiating ROS overproduction. Ethyl cinnamate can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-dependent manner, with respective IC50 values of 0.30 mM and 0.38 mM.
- $29
Size
QTY
D-Menthol
Menthol, (+)-MENTHOL
TN154415356-60-2
D-Menthol ((+)-MENTHOL) is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in the cell body and neurite, suggests that menthol inhibits α±7-nACh receptors in a noncompetitive manner.
- $39
Size
QTY
1-Octanol
Octanol
T10024111-87-5
1-Octanol, a saturated fatty alcohol, functions as an inhibitor of T-type calcium channels (T-channels), showing an inhibitory concentration (IC50) of 4 μM for native T-currents[1]. Additionally, 1-Octanol is recognized for its potential as a biofuel, possessing diesel-like properties[2].
- $39
Size
QTY
Nisoldipine Cited
BAY-k 5552
T016363675-72-9
Nisoldipine (BAY-k 5552) is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent.
- $41
Size
QTY
CitedDiltiazem hydrochloride
RG 83606 HCl, Diltiazem HCl, CRD-401
T011233286-22-5
Diltiazem hydrochloride (RG 83606 HCl) is a benzothiazepine calcium channel blocking agent with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
- $46
Size
QTY
Nifedipine Cited
Procardia XL, Procardia, BAY-a-1040, Adalat
T114621829-25-4
Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.
- $45
Size
QTY
CitedLevetiracetam
UCB L059, SIB-S1
T0192102767-28-2
Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum aminotransferase and alkaline phosphatase elevations during treatment and to rare cases of clinically apparent drug induced liver disease.
- $50
Size
QTY
Otilonium bromide
SP63, Octylonium bromide
T147426095-59-0
Otilonium bromide (SP63) , an antimuscarinic, is utilized as a spasmolytic agent.
- $31
Size
QTY
Methyl homoveratrate
T1201515964-79-1
Methyl homoveratrate, a McN5691 (RWJ-26240) metabolite detected in vivo in plasma, urine, and fecal extracts, functions as a voltage-sensitive calcium channel blocker.
- $31
Size
QTY
Select Batch
Purity:98.49%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TPC2-A1-P is a membrane-permeable two-pore channel 2 (TPC2) agonist that differentially activates two-pore channel 2 (TPC2) and mimics the activation of TPC2 with NAADP and PIP(2). TPC2-A1-P can be used to study neurodegenerative lysosomal storage diseases. |
| Targets&IC50 | TPC2:50 μM (EC50) |
| In vitro | METHODS: Cell lines stably expressing TPC2L11A/L12A were screened with natural and synthetic small molecule libraries using a FLIPR-based Ca2+ assay, and after screening, the structure and activity of TPC2-A1-P (0.1-100 μM) and TPC2-A1-N (T36805) were confirmed by independent chemical synthesis and subsequent retesting. RESULTS: Plateau-responsive full-concentration effect relationships indicated EC50 values of 10.5 and 7.8 μM for TPC2-A1-P and TPC2-A1-N, respectively, and confirmed their Ca2+ solubility in intact cells. [1] |
| Molecular Weight | 460.29 |
| Formula | C20H21BrF3NO3 |
| Cas No. | 2804595-86-4 |
| Smiles | O=C(O)C=1C=C(C=2C=C(Br)C=CC2OC(F)(F)F)N(C1C)CC3CCCCC3 |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL（86.90 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy TPC2-A1-P | purchase TPC2-A1-P | TPC2-A1-P cost | order TPC2-A1-P | TPC2-A1-P chemical structure | TPC2-A1-P in vitro | TPC2-A1-P formula | TPC2-A1-P molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.