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Trabodenoson

Catalog No. T34914Cas No. 871108-05-3
Alias PJ-875, PJ875, PJ 875, INO-8875, INNO-8875, INNO8875, INNO 8875

Trabodenoson (INO-8875) is a selective and potent adenosine A1 receptor agonist, an adenosine analog, for the study of primary open-angle glaucoma.

Trabodenoson

Trabodenoson

Purity: 99.94%
Catalog No. T34914Alias PJ-875, PJ875, PJ 875, INO-8875, INNO-8875, INNO8875, INNO 8875Cas No. 871108-05-3
Trabodenoson (INO-8875) is a selective and potent adenosine A1 receptor agonist, an adenosine analog, for the study of primary open-angle glaucoma.
Pack SizePriceAvailabilityQuantity
1 mg$133In Stock
2 mg$196In Stock
5 mg$328In Stock
10 mg$492In Stock
25 mg$787In Stock
50 mg$1,070In Stock
100 mg$1,430In Stock
1 mL x 10 mM (in DMSO)$363In Stock
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Purity:99.94%
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Product Introduction

Bioactivity
Description
Trabodenoson (INO-8875) is a selective and potent adenosine A1 receptor agonist, an adenosine analog, for the study of primary open-angle glaucoma.
In vitro
Treatment with Trabodenoson significantly increases MMP-2 activity and MMP-14 abundance, while decreasing expression of fibronectin and collagen IV[2].
In vivo
Trabodenoson (6.0%) demonstrates an average IOP drop of 2.45 ± 0.38 mm Hg in young mice over 7 days (downregulation)[2].
In induced eyes, topical trabodenoson significantly upregulates nestin expression in the ONH compared with vehicle-treated non-induced eyes[1].
Trabodenoson-treated eyes show significantly reduced optic nerve (ON) edema compared with vehicle-treated eyes. Additionally, RGC counts are higher in Trabodenoson-treated eyes compared to vehicle, accounting for 74% versus 47% of the contralateral eye[1].
AliasPJ-875, PJ875, PJ 875, INO-8875, INNO-8875, INNO8875, INNO 8875
Chemical Properties
Molecular Weight380.36
FormulaC15H20N6O6
Cas No.871108-05-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (262.91 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6291 mL13.1454 mL26.2909 mL131.4544 mL
5 mM0.5258 mL2.6291 mL5.2582 mL26.2909 mL
10 mM0.2629 mL1.3145 mL2.6291 mL13.1454 mL
20 mM0.1315 mL0.6573 mL1.3145 mL6.5727 mL
50 mM0.0526 mL0.2629 mL0.5258 mL2.6291 mL
100 mM0.0263 mL0.1315 mL0.2629 mL1.3145 mL

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