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TRPC6-PAM-C20
🥰Excellent
Catalog No. T37428Cas No. 667427-75-0
Alias TRPC6-PAM-C20, 3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one
TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator that induces a transient increase in intracellular Ca2+ with an EC50 of 2.37 μM in HEK cells expressing TRPC6 and enhances OAG-induced platelet aggregation.
TRPC6-PAM-C20
🥰Excellent
Catalog No. T37428Alias TRPC6-PAM-C20, 3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-oneCas No. 667427-75-0
TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator that induces a transient increase in intracellular Ca2+ with an EC50 of 2.37 μM in HEK cells expressing TRPC6 and enhances OAG-induced platelet aggregation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $178 | In Stock | |
| 5 mg | $455 | In Stock | |
| 10 mg | $672 | In Stock | |
| 25 mg | $1,060 | In Stock | |
| 50 mg | $1,430 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $490 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator that induces a transient increase in intracellular Ca2+ with an EC50 of 2.37 μM in HEK cells expressing TRPC6 and enhances OAG-induced platelet aggregation. |
| Targets&IC50 | TRPC6 (HEK293 cells):2.37 μM (EC50) |
| Alias | TRPC6-PAM-C20, 3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one |
| Molecular Weight | 363.41 |
| Formula | C22H21NO4 |
| Cas No. | 667427-75-0 |
| Smiles | COc1cc2CC(C)(C)N=C(c2cc1OC)c1cc2ccccc2oc1=O |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90 mg/mL (247.65 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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