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UNC0321
🥰Excellent
Catalog No. T17204Cas No. 1238673-32-9
UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays.
UNC0321
🥰Excellent
Purity: 99.25%
Catalog No. T17204Cas No. 1238673-32-9
UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $39 | In Stock | |
| 5 mg | $94 | In Stock | |
| 10 mg | $147 | In Stock | |
| 25 mg | $289 | In Stock | |
| 50 mg | $455 | In Stock | |
| 100 mg | $655 | In Stock |
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Purity:99.25%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays. |
| Targets&IC50 | G9a:63 pM （ki）, G9a:6-9 nM, GLP:15-23 nM |
| In vitro | UNC0321 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E[1]. UNC0321 reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 11 μM[2]. |
| Molecular Weight | 515.69 |
| Formula | C27H45N7O3 |
| Cas No. | 1238673-32-9 |
| Smiles | COc1cc2c(NC3CCN(C)CC3)nc(nc2cc1OCCOCCN(C)C)N1CCCN(C)CC1 |
| Relative Density. | 1.150 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 3.33 mg/ml (6.46 mM), Sonication is recommended.  | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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