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USP7-797
🥰Excellent
Catalog No. T73234Cas No. 2413944-70-2
Alias USP7-IN-7, USP7797, USP 7-797
USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency (IC50=0.44 nmol), it is effective on both wild-type and mutant p53 tumor cells, and can significantly inhibit the growth of tumor cells and induce apoptosis.
USP7-797
🥰Excellent
Purity: 96.18%
Catalog No. T73234Alias USP7-IN-7, USP7797, USP 7-797Cas No. 2413944-70-2
USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency (IC50=0.44 nmol), it is effective on both wild-type and mutant p53 tumor cells, and can significantly inhibit the growth of tumor cells and induce apoptosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $545 | In Stock |
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CitedSelect Batch
Purity:96.18%
ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency (IC50=0.44 nmol), it is effective on both wild-type and mutant p53 tumor cells, and can significantly inhibit the growth of tumor cells and induce apoptosis. |
| In vitro | Methods: USP7-797 (0-1 μM) was used to treat p53 wild-type hematological cancer cell lines, and cell viability was determined. Results: USP7-797 was cytotoxic to p53 wild-type hematological cancer cell lines, with CC50 values of 0.2, 0.2, 0.4, and 0.1 μM for M07e, OCI-AML5, MOLM13, and MM.IS, respectively. Methods: USP7-797 (0-25 μM) was used to treat p53 mutant cancer cell lines, and cell viability was determined. Results: USP7-797 was cytotoxic to p53 mutant cancer cell lines, with CC50 values of 0.5, 0.2, and 0.2 μM for H526, LA-N-2, and SK-N-DZ, respectively. Methods: USP7-797 (0-2 μM) was used to treat p53 wild-type neuroblastoma cell lines and cell viability was measured. Results: USP7-797 was cytotoxic to p53 wild-type neuroblastoma cell lines, with CC50 values of 1.9, 0.6, and 0.5 μM for SH-SY5Y, CHP-134, and NB-1, respectively. [1] |
| Alias | USP7-IN-7, USP7797, USP 7-797 |
| Molecular Weight | 510.05 |
| Formula | C27H28ClN3O3S |
| Cas No. | 2413944-70-2 |
| Smiles | CC1(C)C2C1C(=O)N(CC=3SC=4C(C3)=NC=CC4C5=C(C[C@@H]6CNCCO6)C(C)=CC(Cl)=C5)C2=O |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (117.64 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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