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YM-53403

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Purity:98.61%

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COA HNMR HPLC LCMS

YM-53403

Catalog No. T29187Cas No. 851331-05-0

YM-53403 is an antiviral activity that effectively inhibits the replication of RSV strains belonging to subgroup A and subgroup B. It can be used to treat respiratory syncytial virus infections.

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Pack Size	Price	Availability
1 mg	$350	In Stock
5 mg	$828	In Stock
10 mg	$1,130	In Stock
25 mg	$1,590	In Stock
50 mg	$1,980	In Stock
100 mg	$2,500	In Stock
500 mg	$4,900	In Stock

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Product Introduction

Bioactivity

Description

YM-53403 is an antiviral activity that effectively inhibits the replication of RSV strains belonging to subgroup A and subgroup B. It can be used to treat respiratory syncytial virus infections.

In vitro

YM-53403 (0.2 μM) reduced plaque with EC50 was 0.20 ± 0.05 μM.[2]
YM-53403 (50 μM) inhibited the life cycle of RSV at around 8 h post-infection in time-dependent, suggesting an inhibitory effect on early transcription and/or replication of the RSV genome. YM-53403 is an attractive compound for the treatment of RSV infection because of its highly potent anti-RSV activity and the new mode of action.[2]

Chemical Properties

Molecular Weight	583.7
Formula	C36H29N3O3S
Cas No.	851331-05-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (102.79 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7132 mL	8.5660 mL	17.1321 mL	85.6604 mL
5 mM	0.3426 mL	1.7132 mL	3.4264 mL	17.1321 mL
10 mM	0.1713 mL	0.8566 mL	1.7132 mL	8.5660 mL
20 mM	0.0857 mL	0.4283 mL	0.8566 mL	4.2830 mL
50 mM	0.0343 mL	0.1713 mL	0.3426 mL	1.7132 mL
100 mM	0.0171 mL	0.0857 mL	0.1713 mL	0.8566 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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Keywords

YM-53403YM53403YM 53403