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Z-WEHD-FMK
Catalog No. TP2161Cas No. 210345-00-9
Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).
Z-WEHD-FMK
Catalog No. TP2161Cas No. 210345-00-9
Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $373 | Backorder | |
| 10 mg | $539 | Backorder | |
| 50 mg | $1,610 | Backorder | |
| 100 mg | Inquiry | Backorder | |
| 200 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM). |
| In vitro | Z-WEHD-FMK (80 μM; 9 hours) nearly completely blocks C. trachomatis-induced cleavage of golgin-84 and increases GM130 expression in cells [1]. Administered 30 minutes before exposure to E. piscicida, Z-WEHD-FMK effectively inhibits 0909I E. piscicida-induced ZF4 cell cytotoxicity and pyroptotic morphology [2]. Z-WEHD-FMK (20 μM; 18-24 hours following exposure to Cr3+, Ni2+, and Co2+) significantly reduces IL-1β release in bone marrow-derived macrophages by 76% to 86% with 200 to 400 ppm Cr3+, by 35% to 45% with 48 ppm or higher Ni2+, and below detection threshold with 6 ppm Co2+, as well as by 40% to 48% with 12 to 24 ppm Co2+ [3]. |
| Molecular Weight | 763.78 |
| Formula | C37H42FN7O10 |
| Cas No. | 210345-00-9 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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