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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $373 | Backorder | |
10 mg | $539 | Backorder | |
50 mg | $1,610 | Backorder | |
100 mg | Inquiry | Backorder | |
200 mg | Inquiry | Backorder |
Description | Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM). |
In vitro | Z-WEHD-FMK (80 μM; 9 hours) elicits a near-complete blockage of C. trachomatis-induced cleavage of golgin-84 and increases GM130 expression in cells [1]. Z-WEHD-FMK (30?min before being exposed to E. piscicida) effectively inhibits 0909I E. piscicida induced ZF4 cells cytotoxicity and pyroptotic morphology [2]. Z-WEHD-FMK (20 μM;18-24 hours following Cr3+, Ni2+, and Co2+) significantly induces a decrease of 76% to 86% in IL-1β release with 200 to 400 ppm Cr3+, it also induces a decrease of 35% to 45% with 48 ppm Ni2+ or higher, Z-WEHD-FMK induced a decrease with 6 ppm Co2+, down to a level below the detection threshold, and a decrease of 40% to 48% with 12 to 24 ppm Co2+ in bone marrow-derived macrophages [3]. |
Molecular Weight | 763.78 |
Formula | C37H42FN7O10 |
Cas No. | 210345-00-9 |
Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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