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Zilucoplan TFA
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Catalog No. T80083
Alias RA101495 TFA
Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, is a potent inhibitor of complement component 5 (C5) with applications in studying immune-mediated necrotising myopathy (IMNM) [1] [2].
Zilucoplan TFA
Zilucoplan TFA
😃Good
Catalog No. T80083Alias RA101495 TFA
Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, is a potent inhibitor of complement component 5 (C5) with applications in studying immune-mediated necrotising myopathy (IMNM) [1] [2].
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Product Introduction
Bioactivity
Chemical Properties
| Description | Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, is a potent inhibitor of complement component 5 (C5) with applications in studying immune-mediated necrotising myopathy (IMNM) [1] [2]. |
| In vitro | Zilucoplan (RA101495; 1-1000 nM; 30 min) suppresses the lipopolysaccharide-induced increase in C5a plasma levels in human whole blood, with an IC50 of 474.5 pM, and achieves a 65.7% reduction at 1 nM [2]. It binds to complement component 5 (C5), inhibiting its cleavage into C5a and C5b and preventing C5b's interaction with C6, thereby obstructing the formation of the membrane attack complex (MAC; C5b-9) and subsequent cell lysis [1]. |
| In vivo | Zilucoplan (RA101495; 10 mg/kg; S.C.; daily for 6 days) effectively inhibits the onset of immune-mediated necrotising myopathy (IMNM) in C5-deficient mice treated with human complement and provides protection against myopathy in C57BL/6 mice [1]. |
| Alias | RA101495 TFA |
| Molecular Weight | 3562.18 (free base) |
| Formula | (C2H4O)nC126H186N24O32.C2HF3O2 |
Storage & Solubility Information
| Storage | keep away from moisture | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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