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RSH-7

Catalog No. T73549Cas No. 2764609-97-2

RSH-7 is a potent dual inhibitor of BTK and FLT3, with IC50s of 47 and 12 nM, respectively.RSH-7 has antiproliferative and antitumor activities, inducing apoptosis and inhibiting BTK and FLT3 signaling.

RSH-7

RSH-7

Purity: 98.31%
Catalog No. T73549Cas No. 2764609-97-2
RSH-7 is a potent dual inhibitor of BTK and FLT3, with IC50s of 47 and 12 nM, respectively.RSH-7 has antiproliferative and antitumor activities, inducing apoptosis and inhibiting BTK and FLT3 signaling.
Pack SizePriceAvailabilityQuantity
1 mg$97In Stock
5 mg$263In Stock
10 mg$428In Stock
25 mg$813In Stock
50 mg$1,180In Stock
100 mg$1,620In Stock
500 mg$3,230In Stock
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Purity:98.31%
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Product Introduction

Bioactivity
Description
RSH-7 is a potent dual inhibitor of BTK and FLT3, with IC50s of 47 and 12 nM, respectively.RSH-7 has antiproliferative and antitumor activities, inducing apoptosis and inhibiting BTK and FLT3 signaling.
Targets&IC50
FLT3:12 nM, BTK:47 nM
In vitro
RSH-7 (1-1000 nM; 72 h) demonstrates antiproliferative activities against Jeko-1, MV-4-11, Molt4, and K562 cells with IC50 values of 17 nM, 3 nM, 11 nM, and 930 nM, respectively.[1] It dose-dependently reduces the expression of p-BTK (TYR223), p-PLCγ(Tyr1217), p-FLT3 (Tyr589), and p-STAT5 (TYR694), and triggers apoptosis while upregulating BAX, p53, and cleaved caspase 3 in Jeko-1 cells.[1]
In vivo
RSH-7 (25, 50 mg/kg; i.p.; daily for 16 days; Female NOD/SCID mice) suppressed tumor growth in a dose-dependent manner, with TGI values of 66.95% and 79.78% at doses of 25 and 50 mg/kg, respectively.[1]
Chemical Properties
Molecular Weight436.49
FormulaC22H25FN8O
Cas No.2764609-97-2
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 75 mg/mL (171.83 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2910 mL11.4550 mL22.9100 mL114.5502 mL
5 mM0.4582 mL2.2910 mL4.5820 mL22.9100 mL
10 mM0.2291 mL1.1455 mL2.2910 mL11.4550 mL
20 mM0.1146 mL0.5728 mL1.1455 mL5.7275 mL
50 mM0.0458 mL0.2291 mL0.4582 mL2.2910 mL
100 mM0.0229 mL0.1146 mL0.2291 mL1.1455 mL

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