Powder: -20°C for 3 years
In solvent: -80°C for 2 years
(1S)-(-)-Alpha-Pinene enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directly binding to the BZD binding site of GABAA receptor.
Description | (1S)-(-)-Alpha-Pinene enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directly binding to the BZD binding site of GABAA receptor. |
In vitro | (1S)-(-)-Alpha-Pinene significantly increased the duration of non-rapid eye movement sleep (NREMS) and reduced the sleep latency by oral administration without affecting duration of rapid eye movement sleep and delta activity. (1S)-(-)-Alpha-Pinene potentiated the GABAA receptor-mediated synaptic response by increasing the decay time constant of sIPSCs in hippocampal CA1 pyramidal neurons[1]. These effects of (1S)-(-)-Alpha-Pinene on sleep and inhibitory synaptic response were mimicked by zolpidem, acting as a modulator for GABAA-BZD receptors, and fully antagonized by flumazenil, an antagonist for GABAA-BZD receptor. (1S)-(-)-Alpha-Pinene was found to bind to aromatic residues of α1- and -γ2 subunits of GABAA-BZD receptors in the molecular model[1]. |
Synonyms | 左旋-α-蒎烯, 左旋-alpha-蒎烯, (1S)-(-)-Alpha-Pinene |
Molecular Weight | 136.23 |
Formula | C10H16 |
CAS No. | 7785-26-4 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 50 mg/mL (367.03 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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(-)-α-Pinene 7785-26-4 代谢 离子通道 神经科学 微生物学 Antibacterial Endogenous Metabolite GABA Receptor Virus Protease Gamma-aminobutyric acid Receptor ()αPinene Bacterial γ-Aminobutyric acid Receptor ( ) α Pinene inhibit (1S)-(-)-Alpha-Pinene Inhibitor inhibitor