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(-)-α-Pinene

Catalog No. TN1202 CAS 7785-26-4

Synonyms: 左旋-α-蒎烯, 左旋-alpha-蒎烯, (1S)-(-)-Alpha-Pinene

(1S)-(-)-Alpha-Pinene enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directly binding to the BZD binding site of GABAA receptor.

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(-)-α-Pinene, CAS 7785-26-4

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Purity: 98%

Biological Description

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Description

In vitro

(1S)-(-)-Alpha-Pinene significantly increased the duration of non-rapid eye movement sleep (NREMS) and reduced the sleep latency by oral administration without affecting duration of rapid eye movement sleep and delta activity. (1S)-(-)-Alpha-Pinene potentiated the GABAA receptor-mediated synaptic response by increasing the decay time constant of sIPSCs in hippocampal CA1 pyramidal neurons[1]. These effects of (1S)-(-)-Alpha-Pinene on sleep and inhibitory synaptic response were mimicked by zolpidem, acting as a modulator for GABAA-BZD receptors, and fully antagonized by flumazenil, an antagonist for GABAA-BZD receptor. (1S)-(-)-Alpha-Pinene was found to bind to aromatic residues of α1- and -γ2 subunits of GABAA-BZD receptors in the molecular model[1].

Synonyms	左旋-α-蒎烯, 左旋-alpha-蒎烯, (1S)-(-)-Alpha-Pinene
Molecular Weight	136.23
Formula	C10H16
CAS No.	7785-26-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (367.03 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Yang H, et al. α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors. Mol Pharmacol. 2016 Nov;90(5):530-539. 2. Kamaitytė-Bukelskienė L, Ložienė K, Labokas J. Dynamics of Isomeric and Enantiomeric Fractions of Pinene in Essential Oil of Picea abies Annual Needles during Growing Season. Molecules. 2021 Apr 8;26(8):2138. 3. Haselton AT, et al. Repellency of α-pinene against the house fly, Musca domestica. Phytochemistry. 2015 Sep;117:469-475.

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Keywords

(-)-α-Pinene 7785-26-4 代谢离子通道神经科学微生物学 Antibacterial Endogenous Metabolite GABA Receptor Virus Protease Gamma-aminobutyric acid Receptor ()αPinene Bacterial γ-Aminobutyric acid Receptor ( ) α Pinene inhibit (1S)-(-)-Alpha-Pinene Inhibitor inhibitor

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