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(E/Z)-GO289

Catalog No. T9356 CAS 694522-87-7

(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function. The discovery of (E/Z)-GO289 provides a direct link between the circadian clock and cancer regulation and reveals unique design principles underlying kinase selectivity.

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(E/Z)-GO289, CAS 694522-87-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	419.3
Formula	C17H15BrN4O2S
CAS No.	694522-87-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 8.13 mg/ml (19.38 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Oshima T, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv. 2019;5(1):eaau9060. Published 2019 Jan 23.

Related Products

Related compounds with same targets

(E/Z)-GO289 Epiblastin A Ellagic acid (hydrate) SR-3029 CK2 inhibitor 2 CKI-7 LH846 PF-5006739

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(E/Z)-GO289 694522-87-7 代谢干细胞 Casein Kinase Inhibitor cancer (E/Z)GO289 circadian (E/Z)-GO-289 cell clock rhythms growth (E/Z) GO289 phosphorylation inhibit inhibitor

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