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(E/Z)-SIB-1893

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Purity:99.92%

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COA HPLC HNMR

(E/Z)-SIB-1893

Catalog No. T23353Cas No. 6266-99-5

(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893. (E)-SIB-1893 is a selective, noncompetitive mGluR5 antagonist with anticonvulsant activity .

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Pack Size	Price	Availability
5 mg	$67	In Stock
10 mg	$118	In Stock
25 mg	$247	In Stock
50 mg	$392	In Stock
100 mg	$592	In Stock
500 mg	$1,280	In Stock

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Product Introduction

Bioactivity

Description	(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893. (E)-SIB-1893 is a selective, noncompetitive mGluR5 antagonist with anticonvulsant activity .
In vitro	We investigated the role of mGluR5 in acute NMDA and glutamate-mediated neurodegeneration in cultured rat cortical cells using the mGluR5 antagonists SIB-1893 (20 or 200 μM; rat cortical cells) and found that they provide significant protection.[4]
In vivo	SIB-1893 (10, 20, and 30 mg/kg; i.p.; 0-180 min) considerably lowered the body temperature in animals at 90, 120, and 180 min after its systemic injection of 30 mg/kg. In contrast, the drug at 10 and 20 mg/kg remained without effect on the body temperature in rats. Based on our preclinical study, one can conclude that SIB-1893 produces hypothermia in freely moving rats in a dose-dependent manner.[1] SIB 1893 (10 and 20 mg/kg; mice; i.p.) did not affect the protective action of valproate, ethosuximide, phenobarbital, and clonazepam in this test. The combined treatment of SIB 1893 with conventional antiepileptic drugs did not lead to motor impairment. Long-term memory disturbances were observed only in the case of the combination of SIB 1893 with phenobarbital.[2]
Alias	SIB 1893

Chemical Properties

Molecular Weight	195.26
Formula	C14H13N
Cas No.	6266-99-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (460.9 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.1214 mL	25.6069 mL	51.2138 mL	256.0688 mL
5 mM	1.0243 mL	5.1214 mL	10.2428 mL	51.2138 mL
10 mM	0.5121 mL	2.5607 mL	5.1214 mL	25.6069 mL
20 mM	0.2561 mL	1.2803 mL	2.5607 mL	12.8034 mL
50 mM	0.1024 mL	0.5121 mL	1.0243 mL	5.1214 mL
100 mM	0.0512 mL	0.2561 mL	0.5121 mL	2.5607 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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