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(R)-(+)-Bay-K-8644

Name: (R)-(+)-Bay-K-8644
Brand: TargetMol
SKU: TQ0145
Price: 40 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. TQ0145Cas No. 98791-67-4

Alias (R)-(+)-Bay K 8644

(R)-(+)-Bay-K-8644 is a Ca2+ channel and dihydropyridine agonist that inhibits Ba2+ currents (IBa), induces central respiratory depression in cats, and inhibits platelet activation through competitive antagonism of thromboxane A2-prostaglandin H2 receptors.

(R)-(+)-Bay-K-8644

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Purity: 96.51%

Catalog No. TQ0145Alias (R)-(+)-Bay K 8644Cas No. 98791-67-4

Pack Size	Price	Availability
1 mg	$52	5 days
5 mg	$123	In Stock
1 mL x 10 mM (in DMSO)	$96	7-10 days

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Purity:96.51%

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COA HNMR LCMS

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Product Introduction

Bioactivity

Description	(R)-(+)-Bay-K-8644 is a Ca2+ channel and dihydropyridine agonist that inhibits Ba2+ currents (IBa), induces central respiratory depression in cats, and inhibits platelet activation through competitive antagonism of thromboxane A2-prostaglandin H2 receptors.
Targets&IC50	Iba:957 nM
In vitro	(R)-(+)-Bay-K-8644, a component of the racemic mixture Bay K 8644, is a well-known L-type Ca2+ channel agonist but functions as an inhibitor of Ba2+ currents (IBa) with an IC50 of 975 nM. At a concentration of 0.5 μM, it reduces IBa to 71±10% of the control level, demonstrating its efficacy in inhibiting Ba2+ currents. Notably, this compound acts as a calcium channel inhibitor, crucial for modulating calcium channel activity [2].
Alias	(R)-(+)-Bay K 8644

Chemical Properties

Molecular Weight	356.3
Formula	C₁₆H₁₅F₃N₂O₄
Cas No.	98791-67-4
Smiles	COC(=O)C1=C(C)NC(C)=C([C@@H]1c1ccccc1C(F)(F)F)[N+]([O-])=O
Relative Density.	1.37g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (280.66 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8066 mL	14.0331 mL	28.0662 mL	140.3312 mL
5 mM	0.5613 mL	2.8066 mL	5.6132 mL	28.0662 mL
10 mM	0.2807 mL	1.4033 mL	2.8066 mL	14.0331 mL
20 mM	0.1403 mL	0.7017 mL	1.4033 mL	7.0166 mL
50 mM	0.0561 mL	0.2807 mL	0.5613 mL	2.8066 mL
100 mM	0.0281 mL	0.1403 mL	0.2807 mL	1.4033 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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