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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $123 | 5 days | |
2 mg | $179 | 5 days | |
5 mg | $299 | In Stock |
Description | (R)-(+)-Bay-K-8644 is a Ca2+ channel inhibitor that inhibits Ba2+ currents (IBa), induces central respiratory depression in cats, and inhibits platelet activation through competitive antagonism of thromboxane A2-prostaglandin H2 receptors. |
In vitro | (R)-(+)-Bay-K-8644, a commonly used L-type Ca2+ channel agonist, is actually a racemic mixture of Bay K 8644. Interestingly, each optical isomer of this compound has opposite effects on Ba2+ currents (IBa), with (R)-(+)-Bay-K-8644 acting as an antagonist and S(-)-Bay K 8644 as an agonist.Specifically, (R)-(+)-Bay-K-8644 functions as an inhibitor of Ba2+ currents (IBa) with an IC50 of 975 nM. When applied at a concentration of 0.5 μM, (R)-(+)-Bay-K-8644 suppresses IBa to 71±10% of the control level. This indicates that (R)-(+)-Bay-K-8644 acts as an effective inhibitor of Ba2+ currents in experimental settings.It's worth noting that (R)-(+)-Bay-K-8644 is classified as a calcium channel inhibitor, further emphasizing its role in modulating calcium channel activity [2]. |
Alias | (R)-(+)-Bay K 8644 |
Molecular Weight | 356.3 |
Formula | C16H15F3N2O4 |
Cas No. | 98791-67-4 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (280.66 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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