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β-Amyloid (1-42), human

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Purity:99.52%

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COA HPLC

β-Amyloid (1-42), human

Catalog No. TP1007Cas No. 107761-42-2

β-Amyloid (1-42), human, is a 42-amino acid peptide integral to the pathogenesis of Alzheimer disease.

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Pack Size	Price	Availability	Quantity
100 μg	$468	35 days

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Product Introduction

Bioactivity

Description	β-Amyloid (1-42), human, is a 42-amino acid peptide integral to the pathogenesis of Alzheimer disease.
In vitro	Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Application of Amyloid β-Peptide (1-42) human (1 to 10 μM) in the bathing solution does not change delayed rectifier K+-current and leakage current, but enhances inactivation of Са2+-current and blocks Са2+-dependent К+-current[1]. At 2.5 μM concentration, Amyloid β-Peptide (1-42) human reduces viability of SH-SY5Y cells to 65%. Results show that Amyloid β-Peptide (1-42) human localizes in both the cytoplasm and nucleus of SH-SY5Y cells after 30 min of incubation and after 8 h. In the latter, large accumulations of Amyloid β-Peptide (1-42) human are seen in the cytoplasm and in the nucleus. Increased APP mRNA levels are also detected upon Amyloid β-Peptide (1-42) human treatment[2].
Alias	β-Amyloid (1-42), human, Amyloid β-Peptide (1-42) human

Chemical Properties

Molecular Weight	4514.04
Formula	C203H311N55O60S
Cas No.	107761-42-2

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (11.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.2215 mL	1.1077 mL	2.2153 mL	11.0766 mL
5 mM	0.0443 mL	0.2215 mL	0.4431 mL	2.2153 mL
10 mM	0.0222 mL	0.1108 mL	0.2215 mL	1.1077 mL

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