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β-Glucuronidase-IN-1
🥰Excellent
Catalog No. T13477Cas No. 484006-66-8
β-Glucuronidase-IN-1 is an E. coli β-glucuronidase (β-glucuronidase) inhibitor with a potent, selective, non-competitive, and orally active IC50 and Ki value of 283 nM and 164 nM, respectively, against E. coli β-glucuronidase.
β-Glucuronidase-IN-1
🥰Excellent
Purity: 98.05%
Catalog No. T13477Cas No. 484006-66-8
β-Glucuronidase-IN-1 is an E. coli β-glucuronidase (β-glucuronidase) inhibitor with a potent, selective, non-competitive, and orally active IC50 and Ki value of 283 nM and 164 nM, respectively, against E. coli β-glucuronidase.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $38 | In Stock | |
| 5 mg | $89 | In Stock | |
| 10 mg | $139 | In Stock | |
| 25 mg | $233 | In Stock | |
| 50 mg | $347 | In Stock | |
| 100 mg | $516 | In Stock | |
| 500 mg | $1,090 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock |
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CitedSelect Batch
Purity:98.05%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | β-Glucuronidase-IN-1 is an E. coli β-glucuronidase (β-glucuronidase) inhibitor with a potent, selective, non-competitive, and orally active IC50 and Ki value of 283 nM and 164 nM, respectively, against E. coli β-glucuronidase. |
| Targets&IC50 | β-glucuronidase (E. coli):283 nM , β-glucuronidase (E. coli):283 nM, β-glucuronidase (E. coli):164 nM(Ki) |
| In vitro | β-Glucuronidase-IN-1 (0.01-100 μM) inhibits E. coli β-glucuronidase activity in a dose-dependent manner(IC50 and Ki of 283 nM and 164 nM, respectively).[1] β-Glucuronidase-IN-1 (100 μM; 24-72 hours) maintains potent efficacy in living bacterial cells with EC50 of 17.7 nM.[1] |
| In vivo | β-Glucuronidase-IN-1 (10 μg; oral gavage; twice per day; 11 days) shields the gastrointestinal epithelium of mice from damage induced by CPT-11, preserving the glandular structure in the treated intestinal tissues.[1] |
| Molecular Weight | 425.54 |
| Formula | C23H27N3O3S |
| Cas No. | 484006-66-8 |
| Smiles | CCOc1ccc(NC(=S)N(CCO)Cc2cc3cc(C)cc(C)c3[nH]c2=O)cc1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (70.5 mM), Sonication and heating to 60℃ are recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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