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Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $33 | In Stock | |
1 g | $48 | In Stock | |
5 g | $68 | In Stock | |
10 g | $89 | In Stock |
Description | HP-β-CD (HP-β-CD) is a widely used drug delivery vehicle to improve stability and bioavailability. |
In vitro | Cell treatment with (2-hydroxypropyl)-β-cyclodextrin can activate the activation of the transcription factor EB (the main regulator of lysosomal function and autophagy) and enhance the cell's autophagy clearance ability[1]. HP-β-CD treatment reduces intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. The IC50 values for HP-β-CD after 72 hours exposure are in the range of 3.86–10.09 mM. HP-β-CD also shows anticancer effects against CML cells expressing a T315I BCR-ABL mutation (that confers resistance to most ABL tyrosine kinase inhibitors), and hypoxia-adapted CML cells that have characteristics of leukemic stem cells. In addition, colony forming ability of human primary AML and CML cells is inhibited by HP-β-CD[2]. |
In vivo | Intraperitoneal injection of HP-β-CD significantly improves survival in leukemia mouse models. Systemic administration of HP-β-CD to mice has no significant adverse effects[2]. |
Alias | Hydroxypropyl-β-cyclodextrin, Hydroxypropyl betadex |
Molecular Weight | 1541.5 |
Formula | C63H112O42 |
Cas No. | 128446-35-5 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (29.19 mM) ![]() H2O: 50 mg/mL, Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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