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1,3-Dicaffeoylquinic acid

Catalog No. T5736 CAS 19870-46-3

Synonyms: CYNARIN, Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-, 1,3-O-Dicaffeoylquinic acid, 1,5-Dicaffeoylquinic acid

1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

1,3-Dicaffeoylquinic acid Chemical Structure

1,3-Dicaffeoylquinic acid, CAS 19870-46-3

Pack Size	Availability	Price/USD	Quantity
20 mg	In stock	$ 140.00
1 mL * 10 mM (in DMSO)	In stock	$ 110.00

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Purity: 98.68%

Purity: 98%

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Description	1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
In vivo	CYNARIN have neuroprotective effects.CYNARIN prevents Aβ(42)-induced neurotoxicity through the activation of PI3K/Akt followed by the stimulation of Trk A, then the inhibition of GSK3β as well as the modulation of Bcl-2/Bax.
Animal Research	The neuroprotective effects of 1,5-DQA against amyloid β(1-42) (Aβ(42))-induced neurotoxicity in primary neuronal culture. To evaluate the neuroprotective effects of 1,5-DQA, primary cultured cortical neurons from neonate rats were pretreated with 1,5-DQA for 2 hours and then treated with 40 μmol/L Aβ(42) for 6 hours. Cell counting kit-8, Hoechst staining and Western blotting were used for detecting the protective mechanism. Comparisons between two groups were evaluated by independent t test, and multiple comparisons were analyzed by one-way analysis of variance (ANOVA).
Source	Natural Products > Asteraceae > Cynara

Synonyms	CYNARIN, Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-, 1,3-O-Dicaffeoylquinic acid, 1,5-Dicaffeoylquinic acid
Molecular Weight	516.45
Formula	C25H24O12
CAS No.	19870-46-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 23 mg/mL (44.53 mM)

References and Literature

1. XIAOHai-bing, CAOXu, WANGLei, et al. 1,5-dicaffeoylquinicacidprotectsprimaryneuronsfromamyloidβ1-42-inducedapoptosisviaPI3K/Aktsignalingpathway[J].2011, 124(17):2628-2635.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Miao medicine Compound Library Anti-Lung Cancer Compound Library Ferroptosis Compound Library Anti-Fibrosis Compound Library Anti-Liver Cancer Compound Library Neural Regeneration Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Antidepressant Compound Library ReFRAME Related Library

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Keywords

1,3-Dicaffeoylquinic acid 19870-46-3 Cytoskeletal Signaling Immunology/Inflammation Metabolism NF-Κb PI3K/Akt/mTOR signaling PI3K Reactive Oxygen Species Akt Phosphoinositide 3-kinase 1,3 Dicaffeoylquinic acid inhibit Protein kinase B Inhibitor 1,3Dicaffeoylquinic acid PKB CYNARIN Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)- 1,3-O-Dicaffeoylquinic acid 1,5-Dicaffeoylquinic acid inhibitor

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