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2-BFI hydrochloride

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Catalog No. T22492Cas No. 89196-95-2

2-BFI hydrochloride is a high-affinity agonist of I2-imidazoline receptor. 2-BFI hydrochloride can be used in studies about protection against stroke and acute inflammatory immune disease.

2-BFI hydrochloride

2-BFI hydrochloride

🥰Excellent
Purity: 100%
Catalog No. T22492Cas No. 89196-95-2
2-BFI hydrochloride is a high-affinity agonist of I2-imidazoline receptor. 2-BFI hydrochloride can be used in studies about protection against stroke and acute inflammatory immune disease.
Pack SizePriceAvailabilityQuantity
5 mg$53In Stock
10 mg$86In Stock
25 mg$183In Stock
50 mg$295In Stock
100 mg$473In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
2-BFI hydrochloride is a high-affinity agonist of I2-imidazoline receptor. 2-BFI hydrochloride can be used in studies about protection against stroke and acute inflammatory immune disease.
In vivo
2-BFI hydrochloride administration after dMCAO improved the neurological deficits and decreased the infarct volume. 2-BFI hydrochloride reduced phosphorylation of mTOR and p70S6, increased IL-10 and TGF-β, and decreased IFN-γ levels in ischemic rats. 2-BFI hydrochloride attenuates ischemic injury by inhibiting the activation of mTOR signaling and modulating neuroinflammation after stroke in rats[2].
Chemical Properties
Molecular Weight222.67
FormulaC11H11ClN2O
Cas No.89196-95-2
SmilesCl.N1=C(NCC1)C=2OC=3C=CC=CC3C2
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 20 mg/mL (89.8 mM)
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM4.4910 mL22.4548 mL44.9095 mL224.5475 mL
5 mM0.8982 mL4.4910 mL8.9819 mL44.9095 mL
10 mM0.4491 mL2.2455 mL4.4910 mL22.4548 mL
20 mM0.2245 mL1.1227 mL2.2455 mL11.2274 mL
50 mM0.0898 mL0.4491 mL0.8982 mL4.4910 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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